{"id":"76714695-a074-55cd-90b2-0ac3911cad8b","stable_key":"220adaab-10d8-5c4e-a3f5-a48700ea794d:agmatine-sulfate-gatm-beta-alanine","predicate":"produces","statement":"Human GATM transferred the amidino group of arginine to beta-alanine, producing guanidinopropionate.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"db5bc65c-82d9-5602-8859-0ab0bb8712cc","mechanism_event_label":"Beta-alanine connects to the guanidino-acid network through a distinct reaction.","subject":{"id":"c8ab5c45-4253-5dd5-be9c-2fcdfa69ac3a","slug":"gatm","display_name":"Human glycine amidinotransferase AGAT / GATM","entity_type_key":"protein"},"object":{"id":"e6d084fe-fe16-527d-a5cf-375696c81b24","slug":"3-guanidinopropionate","display_name":"3-Guanidinopropionate","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"db5bc65c-82d9-5602-8859-0ab0bb8712cc","stable_key":"220adaab-10d8-5c4e-a3f5-a48700ea794d:agmatine-sulfate-gatm-beta-alanine-event","event_type":"observed_relationship","label":"Beta-alanine connects to the guanidino-acid network through a distinct reaction.","description":"Human GATM transferred the amidino group of arginine to beta-alanine, producing guanidinopropionate.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c8ab5c45-4253-5dd5-be9c-2fcdfa69ac3a","slug":"gatm","display_name":"Human glycine amidinotransferase AGAT / GATM","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e6d084fe-fe16-527d-a5cf-375696c81b24","slug":"3-guanidinopropionate","display_name":"3-Guanidinopropionate","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ae2dddf4-ce04-57e3-8a06-7ed9fdc24554","slug":"agmatine-sulfate","display_name":"Agmatine Sulfate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e2f83eb4-99ed-5050-87d3-3e4701d05c1a","slug":"agmatine","display_name":"Agmatine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"288f19a6-62f0-51fe-8e6d-366388b6b16d","slug":"beta-alanine","display_name":"Beta-alanine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text; Figure 4B","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Recombinant human enzyme assay.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No competition magnitude with glycine or taurine in a living person was established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Agmatine Sulfate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"agmatine-sulfate","display_name":"Agmatine Sulfate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Beta-alanine connects to the guanidino-acid network through a distinct reaction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Guanidino acid hydrolysis by the human enzyme annotated as agmatinase. · 2022 · https://pubmed.ncbi.nlm.nih.gov/36543883/ · DOI 10.1038/s41598-022-26655-4","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6924b62a-dd9b-56c2-889c-c7404da76de4","evidence_kind":"source_excerpt","locator":"Lines 204-210","start_line":204,"end_line":210,"excerpt":"## agmatine-sulfate-gatm-beta-alanine\nBeta-alanine connects to the guanidino-acid network through a distinct reaction.\nHuman GATM transferred the amidino group of arginine to beta-alanine, producing guanidinopropionate.\nModel: Recombinant human enzyme assay.\nLimitations: No competition magnitude with glycine or taurine in a living person was established.\nEvidence access: Primary full text; Figure 4B\nGuanidino acid hydrolysis by the human enzyme annotated as agmatinase. · 2022 · https://pubmed.ncbi.nlm.nih.gov/36543883/ · DOI 10.1038/s41598-022-26655-4","model_system":"Recombinant human enzyme assay.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e0426971-7d13-51c9-8354-6547b664f1cf","stable_key":"import-220adaab-10d8-5c4e-a3f5-a48700ea794d","title":"Agmatine Sulfate: transport, guanidino metabolism, ion channels and cross-nutrient mechanisms (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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