{"id":"76522027-b446-5d37-9f42-5899c7212d48","stable_key":"dc8975b1-95ff-5d9b-be17-a1c04610cca7:mo-low-intake-conservation","predicate":"reduces_turnover_during_low_intake","statement":"At 22 micrograms/day, molybdenum turnover slowed and balance improved with time, although balance was not consistently achieved.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"486708f6-80c6-5c3b-abee-7831b8a94978","mechanism_event_label":"The body conserved molybdenum during prolonged low intake.","subject":{"id":"36447b98-3392-559f-b76c-035726a2538e","slug":"molybdenum","display_name":"Molybdenum","entity_type_key":"nutrient_element"},"object":{"id":"a37ec75f-b755-5e16-aaef-7d07e2fec5b2","slug":"human-molybdenum-balance","display_name":"Human molybdenum balance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"486708f6-80c6-5c3b-abee-7831b8a94978","stable_key":"dc8975b1-95ff-5d9b-be17-a1c04610cca7:mo-low-intake-conservation-event","event_type":"observed_intervention","label":"The body conserved molybdenum during prolonged low intake.","description":"At 22 micrograms/day, molybdenum turnover slowed and balance improved with time, although balance was not consistently achieved.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"36447b98-3392-559f-b76c-035726a2538e","slug":"molybdenum","display_name":"Molybdenum","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a37ec75f-b755-5e16-aaef-7d07e2fec5b2","slug":"human-molybdenum-balance","display_name":"Human molybdenum balance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/molybdenum-research/7733035.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a566c89562d46c98608ced96cc37d0e248deede57a8164ed8bb993c2d8818bc6\", \"start_char\": 0, \"end_char\": 1265, \"text_sha256\": \"a566c89562d46c98608ced96cc37d0e248deede57a8164ed8bb993c2d8818bc6\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Stable-isotope depletion/repletion study in four young men","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"22 micrograms/day for 102 days, then 467 micrograms/day for 18 days","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Negative balance is not the same as symptomatic deficiency; requirement estimates are specific to this small cohort.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Molybdenum research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"molybdenum","display_name":"Molybdenum","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The body conserved molybdenum during prolonged low intake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mo-p7733035] Molybdenum absorption, excretion, and retention studied with stable isotopes in young men during depletion and repletion. 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