{"id":"765209f8-3f32-58e0-998b-805a98a63120","stable_key":"220adaab-10d8-5c4e-a3f5-a48700ea794d:agmatine-sulfate-azin2-identity","predicate":"lacks_in_assay","statement":"Human ODC paralogue/AZIN2 had no intrinsic arginine-decarboxylase activity in the reported experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"dd33c143-657e-5860-85d7-9c82a77acf1c","mechanism_event_label":"Do not assign a human agmatine-synthesis reaction to AZIN2 just because older names suggest it.","subject":{"id":"60429969-802f-5ede-9184-a77538b844d1","slug":"azin2","display_name":"Human antizyme inhibitor 2 / AZIN2","entity_type_key":"protein"},"object":{"id":"d0da8e80-dce1-5e6e-a100-4d64163d3bb7","slug":"human-azin2-arginine-decarboxylase-activity","display_name":"Putative human AZIN2 arginine-decarboxylase activity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"dd33c143-657e-5860-85d7-9c82a77acf1c","stable_key":"220adaab-10d8-5c4e-a3f5-a48700ea794d:agmatine-sulfate-azin2-identity-event","event_type":"observed_relationship","label":"Do not assign a human agmatine-synthesis reaction to AZIN2 just because older names suggest it.","description":"Human ODC paralogue/AZIN2 had no intrinsic arginine-decarboxylase activity in the reported experiments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"60429969-802f-5ede-9184-a77538b844d1","slug":"azin2","display_name":"Human antizyme inhibitor 2 / AZIN2","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d0da8e80-dce1-5e6e-a100-4d64163d3bb7","slug":"human-azin2-arginine-decarboxylase-activity","display_name":"Putative human AZIN2 arginine-decarboxylase activity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ae2dddf4-ce04-57e3-8a06-7ed9fdc24554","slug":"agmatine-sulfate","display_name":"Agmatine Sulfate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e2f83eb4-99ed-5050-87d3-3e4701d05c1a","slug":"agmatine","display_name":"Agmatine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human protein biochemical and cell studies.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This rejects that assignment, not every possible source of mammalian agmatine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Agmatine Sulfate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"agmatine-sulfate","display_name":"Agmatine Sulfate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Do not assign a human agmatine-synthesis reaction to AZIN2 just because older names suggest it.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase. · 2008 · https://pubmed.ncbi.nlm.nih.gov/17900240/ · DOI 10.1042/BJ20071004","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"93f07c6d-9d8d-539c-923e-484feb638cb8","evidence_kind":"source_excerpt","locator":"Lines 172-178","start_line":172,"end_line":178,"excerpt":"## agmatine-sulfate-azin2-identity\nDo not assign a human agmatine-synthesis reaction to AZIN2 just because older names suggest it.\nHuman ODC paralogue/AZIN2 had no intrinsic arginine-decarboxylase activity in the reported experiments.\nModel: Human protein biochemical and cell studies.\nLimitations: This rejects that assignment, not every possible source of mammalian agmatine.\nEvidence access: Primary abstract\nHuman ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase. · 2008 · https://pubmed.ncbi.nlm.nih.gov/17900240/ · DOI 10.1042/BJ20071004","model_system":"Human protein biochemical and cell studies.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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