{"id":"7637b579-30de-5ead-9fe6-b624b086da50","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-osteoclast-resorption","predicate":"reduces","statement":"Silicon treatment reduced resorption pits and released type I collagen fragments on bone slices.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"89663a37-f0f1-527b-bb80-258c5ac33b3a","mechanism_event_label":"The study measured matrix breakdown as well as cell markers.","subject":{"id":"1ff7d527-b221-5c48-b48d-a015f7aebe6e","slug":"osa-enriched-silicon-osteoclast-preparation","display_name":"Silicon preparation containing 75% orthosilicic acid","entity_type_key":"chemical_species"},"object":{"id":"9eb4b9e0-1ee7-5283-bdc1-c321d2d0da74","slug":"human-osteoclast-bone-resorption","display_name":"Human osteoclast bone resorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"89663a37-f0f1-527b-bb80-258c5ac33b3a","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-osteoclast-resorption-event","event_type":"observed_relationship","label":"The study measured matrix breakdown as well as cell markers.","description":"Silicon treatment reduced resorption pits and released type I collagen fragments on bone slices.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1ff7d527-b221-5c48-b48d-a015f7aebe6e","slug":"osa-enriched-silicon-osteoclast-preparation","display_name":"Silicon preparation containing 75% orthosilicic acid","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9eb4b9e0-1ee7-5283-bdc1-c321d2d0da74","slug":"human-osteoclast-bone-resorption","display_name":"Human osteoclast bone resorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"11b1cdb5-1b10-586b-9917-b4da18ac072f","slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"091a1ec0-5867-5659-b199-b73a1ac8b9c6","slug":"human-type-i-collagen","display_name":"Human type I collagen","entity_type_key":"protein_complex"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"6db3cbef-401d-5ef3-ab6f-e6949aab7b40","slug":"human-osa-osteoclast-differentiation","display_name":"Human osteoclast differentiation under silicon exposure","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human osteoclast bone-disc assays; 50 micrograms Si/mL.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not demonstrated clinical fracture prevention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"The study measured matrix breakdown as well as cell markers.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Orthosilicic acid inhibits human osteoclast differentiation and bone resorption. · 2024 · https://pubmed.ncbi.nlm.nih.gov/39405281/ · DOI 10.1371/journal.pone.0312169","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c3d67f62-4e5e-521e-816c-82e7fbd9b5f3","evidence_kind":"source_excerpt","locator":"Lines 264-270","start_line":264,"end_line":270,"excerpt":"## silica-osteoclast-resorption\nThe study measured matrix breakdown as well as cell markers.\nSilicon treatment reduced resorption pits and released type I collagen fragments on bone slices.\nModel: Human osteoclast bone-disc assays; 50 micrograms Si/mL.\nLimitations: Not demonstrated clinical fracture prevention.\nEvidence access: Primary full text\nOrthosilicic acid inhibits human osteoclast differentiation and bone resorption. · 2024 · https://pubmed.ncbi.nlm.nih.gov/39405281/ · DOI 10.1371/journal.pone.0312169","model_system":"Human osteoclast bone-disc assays; 50 micrograms Si/mL.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc4b461e-dd46-57ab-8213-8aeb7ff9e8d0","stable_key":"import-3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd","title":"Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"e05d81962a1ca6cbfc68fce4fd3dbcdea67c8e61332c19f4fec5d0c3ab8bf1b9","revision_id":"6433ed49-a331-571b-a611-21e56c3ce4bc","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}