{"id":"7630c897-2c83-5628-82d8-fd61bb5e9174","stable_key":"6612c190-1948-5bcf-bbe3-a7f6c50fa3cf:l-proline-rpe-diet-model","predicate":"improves","statement":"Dietary proline improved visual function in an acute model of RPE-induced retinal degeneration.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"403a06f1-2788-5a2c-90e1-eb84cc7605b6","mechanism_event_label":"A dietary intervention helped in a specific experimental eye-injury model.","subject":{"id":"70ccd53c-83ad-5251-a4f5-6370973bc40a","slug":"l-proline","display_name":"L-Proline","entity_type_key":"small_molecule"},"object":{"id":"37645e44-54d7-575a-8758-8009d68b30ec","slug":"mouse-acute-rpe-injury-visual-response","display_name":"Visual response in the acute mouse RPE-injury model","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"403a06f1-2788-5a2c-90e1-eb84cc7605b6","stable_key":"6612c190-1948-5bcf-bbe3-a7f6c50fa3cf:l-proline-rpe-diet-model-event","event_type":"observed_relationship","label":"A dietary intervention helped in a specific experimental eye-injury model.","description":"Dietary proline improved visual function in an acute model of RPE-induced retinal degeneration.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"70ccd53c-83ad-5251-a4f5-6370973bc40a","slug":"l-proline","display_name":"L-Proline","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"37645e44-54d7-575a-8758-8009d68b30ec","slug":"mouse-acute-rpe-injury-visual-response","display_name":"Visual response in the acute mouse RPE-injury model","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse acute RPE-injury study; primary abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Diet concentration and injury-protocol details are not asserted from the abstract; this does not establish treatment for chronic human AMD.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Proline collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-proline","display_name":"L-Proline","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A dietary intervention helped in a specific experimental eye-injury model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Proline mediates metabolic communication between retinal pigment epithelial cells and the retina. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31110046/ · DOI 10.1074/jbc.RA119.007983","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b4f8e7e6-4d94-5c47-96a2-22dc518fb0f8","evidence_kind":"source_excerpt","locator":"Lines 342-348","start_line":342,"end_line":348,"excerpt":"## l-proline-rpe-diet-model\nA dietary intervention helped in a specific experimental eye-injury model.\nDietary proline improved visual function in an acute model of RPE-induced retinal degeneration.\nModel: Mouse acute RPE-injury study; primary abstract.\nLimitations: Diet concentration and injury-protocol details are not asserted from the abstract; this does not establish treatment for chronic human AMD.\nEvidence access: Primary abstract\nProline mediates metabolic communication between retinal pigment epithelial cells and the retina. · 2019 · https://pubmed.ncbi.nlm.nih.gov/31110046/ · DOI 10.1074/jbc.RA119.007983","model_system":"Mouse acute RPE-injury study; primary abstract.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e5aa7fc5-ee52-5376-8169-416082a89fd1","stable_key":"import-6612c190-1948-5bcf-bbe3-a7f6c50fa3cf","title":"L-Proline: synthesis, collagen processing, redox metabolism and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"7b7f1981f9c7897fbb6baa19425bdc19dede78ad4d66fa554394b8337c7366fb","revision_id":"4971a925-fa70-59f8-8030-d3029a18a62f","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}