{"id":"761c63fe-7fa8-55f8-b3d4-846343b178db","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-scot","predicate":"activated_to","statement":"OXCT1 transfers CoA from succinyl-CoA to acetoacetate, yielding acetoacetyl-CoA and succinate.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2ce04b61-3422-54f1-9bf9-d56afb7978c2","mechanism_event_label":"Using ketones requires a separate activation step.","subject":{"id":"1b77cb4a-1f79-50e2-b4f0-fd0953cb914e","slug":"acetoacetate","display_name":"Acetoacetate","entity_type_key":"small_molecule"},"object":{"id":"080298d2-4743-5488-aa8d-48c00985fb7b","slug":"acetoacetyl-coa","display_name":"Acetoacetyl-CoA","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"2ce04b61-3422-54f1-9bf9-d56afb7978c2","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-scot-event","event_type":"observed_relationship","label":"Using ketones requires a separate activation step.","description":"OXCT1 transfers CoA from succinyl-CoA to acetoacetate, yielding acetoacetyl-CoA and succinate.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1b77cb4a-1f79-50e2-b4f0-fd0953cb914e","slug":"acetoacetate","display_name":"Acetoacetate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"080298d2-4743-5488-aa8d-48c00985fb7b","slug":"acetoacetyl-coa","display_name":"Acetoacetyl-CoA","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0f897c17-054b-5846-b5c6-90647d7e8cbf","slug":"oxct1","display_name":"Human succinyl-CoA:3-ketoacid CoA transferase / OXCT1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"1b7ace51-f2c3-583b-89ed-196fa96d2b0a","slug":"succinyl-coa","display_name":"Succinyl-CoA","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"462f63ce-a2c1-5312-9c14-70b8b12e1d6e","slug":"succinate","display_name":"Succinate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract and indexed full-text introduction, PMC3825524","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human SCOT structure; described ketolysis reaction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Production of ketones and ability to use them are different capacities.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"}},{"dimension":"plain_language","value_text":"Using ketones requires a separate activation step.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"A structural mapping of mutations causing succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23420214/ · DOI 10.1007/s10545-013-9589-z","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c429964a-09c9-5bef-90f1-c2912f65f243","evidence_kind":"source_excerpt","locator":"Lines 144-150","start_line":144,"end_line":150,"excerpt":"## fast-scot\nUsing ketones requires a separate activation step.\nOXCT1 transfers CoA from succinyl-CoA to acetoacetate, yielding acetoacetyl-CoA and succinate.\nModel: Human SCOT structure; described ketolysis reaction.\nLimitations: Production of ketones and ability to use them are different capacities.\nEvidence access: Primary abstract and indexed full-text introduction, PMC3825524\nA structural mapping of mutations causing succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23420214/ · DOI 10.1007/s10545-013-9589-z","model_system":"Human SCOT structure; described ketolysis reaction.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"921d1eb5-2c88-52b9-9898-60b2b5bf6029","stable_key":"import-c9aa15a1-8ba2-5913-b2dd-372af304bf87","title":"Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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