{"id":"75e6e04d-78e0-5577-be81-03e0f9285806","stable_key":"e3f6ce02-0bd7-5103-acc1-68503ab6751b:mdd-carnitine-null","predicate":"no_detected_change_in_recorded_comparison","statement":"Free carnitine was not reduced in the same MDD comparison despite lower ALCAR.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"a93c4d66-27ca-54ca-b102-0f101738dd6e","mechanism_event_label":"Free carnitine was not reduced in the same MDD comparison despite lower ALCAR.","subject":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"object":{"id":"20a81d96-d276-51f4-b1e0-a98b63d49dfa","slug":"human-mdd-free-carnitine","display_name":"Free carnitine in human major depressive disorder","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a93c4d66-27ca-54ca-b102-0f101738dd6e","stable_key":"e3f6ce02-0bd7-5103-acc1-68503ab6751b:mdd-carnitine-null-event","event_type":"experimental_observation","label":"Free carnitine was not reduced in the same MDD comparison despite lower ALCAR.","description":"### mdd-carnitine-null\n\nFree carnitine was not reduced in the same MDD comparison despite lower ALCAR.\nDistinct metabolite pools cannot be collapsed into a generalized carnitine-deficiency diagnosis.\nModel and exposure: Same human case-control cohorts.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Acetyl-l-carnitine deficiency in patients with major depressive disorder. | 2018 | https://pubmed.ncbi.nlm.nih.gov/30061399/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC6112703/ | https://doi.org/10.1073/pnas.1801609115 | Access: Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"role":"tested factor","stoichiometry":null,"state_label":"MDD cohort membership (observational)","sequence_order":0,"notes":""},{"entity":{"id":"20a81d96-d276-51f4-b1e0-a98b63d49dfa","slug":"human-mdd-free-carnitine","display_name":"Free carnitine in human major depressive disorder","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"no_detected_change","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"MDD cohort membership (observational)\", \"comparator\": \"Age/sex-matched controls\", \"endpoint\": \"Free carnitine was not reduced in the same MDD comparison despite lower ALCAR.\", \"effect_direction\": \"no_detected_change\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Same human case-control cohorts.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived curation with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Acetyl-L-carnitine collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"acetylcarnitine","display_name":"Acetyl-L-carnitine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Free carnitine was not reduced in the same MDD comparison despite lower ALCAR.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Acetyl-l-carnitine deficiency in patients with major depressive disorder. | https://pubmed.ncbi.nlm.nih.gov/30061399/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC6112703/ | https://doi.org/10.1073/pnas.1801609115","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference mdd-carnitine-null; Distinct metabolite pools cannot be collapsed into a generalized carnitine-deficiency diagnosis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"f78edd08-18e8-5762-bdb7-12ec2b75eaf4","evidence_kind":"source_excerpt","locator":"Lines 579-585","start_line":579,"end_line":585,"excerpt":"### mdd-carnitine-null\n\nFree carnitine was not reduced in the same MDD comparison despite lower ALCAR.\nDistinct metabolite pools cannot be collapsed into a generalized carnitine-deficiency diagnosis.\nModel and exposure: Same human case-control cohorts.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Acetyl-l-carnitine deficiency in patients with major depressive disorder. | 2018 | https://pubmed.ncbi.nlm.nih.gov/30061399/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC6112703/ | https://doi.org/10.1073/pnas.1801609115 | Access: Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.","model_system":"Same human case-control cohorts.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2588f904-245a-597a-8a12-65118013fb90","stable_key":"import-e3f6ce02-0bd7-5103-acc1-68503ab6751b","title":"Acetyl-L-carnitine: detailed mechanisms of action (reviewed 6 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original review of primary studies and clearly identified official records. Exact primary access is stated; no independent replication is claimed.","file_path":"","sha256":"84cc82d6fbb0fd5d73c4ce779e9f88e7f0184ba2d29b18ad0f153815380f2975","revision_id":"dac7a950-dbe5-5c7a-9c70-2ea711d5c71a","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}