{"id":"75e57c16-efcf-5251-a557-93137d9d0f78","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-pk-ten","predicate":"has_measured_bioavailability","statement":"A 10 g oral dose had approximately 20% absolute bioavailability in the crossover study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"57738ba3-0e37-500a-8f34-cbefdd4d26de","mechanism_event_label":"A second protocol produced a different exposure estimate.","subject":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"object":{"id":"95843b11-d77b-5ef6-8394-80d62b0620c8","slug":"arginine-oral-bioavailability","display_name":"Absolute oral arginine bioavailability","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"57738ba3-0e37-500a-8f34-cbefdd4d26de","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-pk-ten-event","event_type":"observed_relationship","label":"A second protocol produced a different exposure estimate.","description":"A 10 g oral dose had approximately 20% absolute bioavailability in the crossover study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"95843b11-d77b-5ef6-8394-80d62b0620c8","slug":"arginine-oral-bioavailability","display_name":"Absolute oral arginine bioavailability","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Ten healthy volunteers; dietary baseline-variation control and 30 g intravenous comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Dose, endogenous baseline and modeling differ from the 6 g study. No mechanism resolving the difference is established here.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Arginine collection; tissue, species, dose and formulation distinctions retained.","comparator":null,"unit":null,"notes":"","entity":{"slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A second protocol produced a different exposure estimate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Pharmacokinetics of intravenous and oral L-arginine in normal volunteers. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10215749/ · DOI 10.1046/j.1365-2125.1999.00883.x","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e7ed4bb0-22df-5db2-b23a-a3e56b359ed7","evidence_kind":"source_excerpt","locator":"Lines 350-356","start_line":350,"end_line":356,"excerpt":"## arg-pk-ten\nA second protocol produced a different exposure estimate.\nA 10 g oral dose had approximately 20% absolute bioavailability in the crossover study.\nModel: Ten healthy volunteers; dietary baseline-variation control and 30 g intravenous comparison.\nLimitations: Dose, endogenous baseline and modeling differ from the 6 g study. No mechanism resolving the difference is established here.\nEvidence access: Primary abstract\nPharmacokinetics of intravenous and oral L-arginine in normal volunteers. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10215749/ · DOI 10.1046/j.1365-2125.1999.00883.x","model_system":"Ten healthy volunteers; dietary baseline-variation control and 30 g intravenous comparison.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; primary evidence access stated per claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bb9a67ea-904f-5b8a-93a4-459081212bdd","stable_key":"import-fd37d270-3395-56d6-9f1c-ddda56e606f6","title":"L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"ec0e9a3fb72b7485534e4372a074ac7624a399ff962e55690eb462217b5149ec","revision_id":"af027270-5535-51ae-85ff-9c76c518c962","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}