{"id":"75b1f9e8-cca6-537c-a99b-c8d5c34777ba","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:ca-synaptotagmin-calcium-release","predicate":"regulates","statement":"Calcium binding to synaptotagmin 1 participates in triggering evoked neurotransmitter release at mouse synapses.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c73bbbb5-3ded-52b6-9526-82348db02669","mechanism_event_label":"Synaptotagmin 1 helps convert a calcium signal into vesicle release.","subject":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"object":{"id":"b1115a80-1f08-5f9d-a845-260667be514b","slug":"evoked-synaptic-vesicle-release","display_name":"Evoked synaptic vesicle release","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c73bbbb5-3ded-52b6-9526-82348db02669","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:ca-synaptotagmin-calcium-release-event","event_type":"regulation","label":"Synaptotagmin 1 helps convert a calcium signal into vesicle release.","description":"Calcium binding to synaptotagmin 1 participates in triggering evoked neurotransmitter release at mouse synapses.","status":"provisional","compartment":{"slug":"synaptic-vesicle-membrane","display_name":"Synaptic vesicle membrane"},"participants":[{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"trigger_ligand","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"39c2a9ab-97b9-5a59-a016-e2e150e5c2b6","slug":"syt1","display_name":"Synaptotagmin 1 / SYT1","entity_type_key":"protein"},"role":"calcium_sensor","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b1115a80-1f08-5f9d-a845-260667be514b","slug":"evoked-synaptic-vesicle-release","display_name":"Evoked synaptic vesicle release","entity_type_key":"cellular_process"},"role":"regulated_process","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"636ec379-4684-581d-ae59-7d495ae26e09","slug":"synaptic-vesicle-membrane","display_name":"Synaptic vesicle membrane","entity_type_key":"organelle"},"role":"experimental_location","stoichiometry":null,"state_label":"","sequence_order":3,"notes":"Study location; presence here is not a separate transport or causal claim."},{"entity":{"id":"f0b6bcb6-5d41-5d9d-af9f-6af1a94d5c5a","slug":"plasma-membrane","display_name":"Plasma membrane","entity_type_key":"organelle"},"role":"experimental_location","stoichiometry":null,"state_label":"","sequence_order":4,"notes":"Study location; presence here is not a separate transport or causal claim."}]},"contexts":[{"dimension":"compartment_description","value_text":"Presynaptic vesicle-plasma-membrane interface","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse synaptotagmin-1 knock-in and cultured neuronal release measurements","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"SYT1-dependent evoked release; does not establish the sensor for every secretory cell or all release modes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Calcium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Synaptotagmin 1 helps convert a calcium signal into vesicle release.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ca-fernandezchacon2001] Synaptotagmin I functions as a calcium regulator of release probability (2001). https://pubmed.ncbi.nlm.nih.gov/11242035/ DOI: 10.1038/35065004","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"research_relationship_category","value_text":"regulation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Cultured neurons","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b942719f-ff49-5d1b-ad4c-92d435f7e1ac","evidence_kind":"source_excerpt","locator":"Lines 783-794","start_line":783,"end_line":794,"excerpt":"### ca-synaptotagmin-calcium-release\nCalcium binding to synaptotagmin 1 participates in triggering evoked neurotransmitter release at mouse synapses.\nCondition category: normal\nnutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Synaptotagmin 1 helps convert a calcium signal into vesicle release.\norganism: Mus musculus\ntissue_or_cell_type: Cultured neurons\nexperimental_model: Mouse synaptotagmin-1 knock-in and cultured neuronal release measurements\nlimitations: SYT1-dependent evoked release; does not establish the sensor for every secretory cell or all release modes.\nresearch_relationship_category: regulation\ncompartment_description: Presynaptic vesicle-plasma-membrane interface\n[ca-fernandezchacon2001] Synaptotagmin I functions as a calcium regulator of release probability (2001). https://pubmed.ncbi.nlm.nih.gov/11242035/ DOI: 10.1038/35065004","model_system":"Mouse synaptotagmin-1 knock-in and cultured neuronal release measurements","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ca-fernandezchacon2001] Synaptotagmin I functions as a calcium regulator of release probability (2001). https://pubmed.ncbi.nlm.nih.gov/11242035/ DOI: 10.1038/35065004","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3c083fa0-59c6-50e9-af42-678d0e3c1006","stable_key":"import-434e1e27-eb90-583a-956b-62472726ffba","title":"Calcium: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"965c934d6b147f2b62f8d45ce6d7a87681a600bfe5c46a585b4704889afd3fc1","revision_id":"543ec48b-4f70-5197-9d76-f5a3c443664c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}