{"id":"753d4570-ad3a-5d4c-8ad3-04e3f269193b","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-insulin-sodium","predicate":"reduces","statement":"Urinary sodium excretion fell from 401 to 213 microequivalents/min without changes in GFR, renal blood flow or aldosterone.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"d9d33a62-a7c2-58d6-8013-fefea5d1bf65","mechanism_event_label":"Insulin changed kidney sodium retention.","subject":{"id":"d7ab69c0-cd7d-587c-b315-47af56493182","slug":"insulin","display_name":"Insulin","entity_type_key":"protein"},"object":{"id":"b14101cf-5d17-51bd-9e48-5e69efb44e62","slug":"renal-sodium-excretion","display_name":"Renal sodium excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d9d33a62-a7c2-58d6-8013-fefea5d1bf65","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-insulin-sodium-event","event_type":"observed_relationship","label":"Insulin changed kidney sodium retention.","description":"Urinary sodium excretion fell from 401 to 213 microequivalents/min without changes in GFR, renal blood flow or aldosterone.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d7ab69c0-cd7d-587c-b315-47af56493182","slug":"insulin","display_name":"Insulin","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b14101cf-5d17-51bd-9e48-5e69efb44e62","slug":"renal-sodium-excretion","display_name":"Renal sodium excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Six water-loaded healthy subjects; 120-minute euglycemic insulin infusion, 98–193 microU/mL.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Insulin-clamp mechanism, not a fasting or refeeding-syndrome trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"}},{"dimension":"plain_language","value_text":"Insulin changed kidney sodium retention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man. · 1975 · https://pubmed.ncbi.nlm.nih.gov/1120786/ · DOI 10.1172/JCI107996","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e6fd9124-d094-5209-93bd-15a514ddb876","evidence_kind":"source_excerpt","locator":"Lines 448-454","start_line":448,"end_line":454,"excerpt":"## fast-insulin-sodium\nInsulin changed kidney sodium retention.\nUrinary sodium excretion fell from 401 to 213 microequivalents/min without changes in GFR, renal blood flow or aldosterone.\nModel: Six water-loaded healthy subjects; 120-minute euglycemic insulin infusion, 98–193 microU/mL.\nLimitations: Insulin-clamp mechanism, not a fasting or refeeding-syndrome trial.\nEvidence access: Primary abstract\nThe effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man. · 1975 · https://pubmed.ncbi.nlm.nih.gov/1120786/ · DOI 10.1172/JCI107996","model_system":"Six water-loaded healthy subjects; 120-minute euglycemic insulin infusion, 98–193 microU/mL.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"921d1eb5-2c88-52b9-9898-60b2b5bf6029","stable_key":"import-c9aa15a1-8ba2-5913-b2dd-372af304bf87","title":"Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"991b7fd94be84c0f1e622e0672eda03d600b388dfd7825e219aa1678d1c7983a","revision_id":"ce85d3f4-4eaf-5aee-bddb-0f0ce7fe2211","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}