{"id":"7537a20a-256a-5fa0-9d7b-1b6de30404cc","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-microbial-first-step","predicate":"converts_to","statement":"Anaerobic E. ramulus wK1 converted luteolin through an identified eriodictyol intermediate.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7c07aae6-25b7-5849-8d60-0b053d46afcd","mechanism_event_label":"Gut bacteria can change the flavone scaffold.","subject":{"id":"5b74d97d-93aa-5a34-95f1-e90b14b2e7eb","slug":"eubacterium-ramulus-wk1","display_name":"Eubacterium ramulus strain wK1","entity_type_key":"organism"},"object":{"id":"7d1fbea5-a816-58de-b34d-15abe1d7da74","slug":"eriodictyol","display_name":"Eriodictyol","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"7c07aae6-25b7-5849-8d60-0b053d46afcd","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-microbial-first-step-event","event_type":"observed_relationship","label":"Gut bacteria can change the flavone scaffold.","description":"Anaerobic E. ramulus wK1 converted luteolin through an identified eriodictyol intermediate.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5b74d97d-93aa-5a34-95f1-e90b14b2e7eb","slug":"eubacterium-ramulus-wk1","display_name":"Eubacterium ramulus strain wK1","entity_type_key":"organism"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7d1fbea5-a816-58de-b34d-15abe1d7da74","slug":"eriodictyol","display_name":"Eriodictyol","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Resting bacterial cells, HPLC and mass spectrometry.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Human-derived strain, not a measured conversion fraction in a person.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Gut bacteria can change the flavone scaffold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Degradation of quercetin and luteolin by Eubacterium ramulus. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11722907/ · DOI 10.1128/AEM.67.12.5558-5567.2001","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d8932eb4-54c6-5453-955c-1b21c3f85419","evidence_kind":"source_excerpt","locator":"Lines 252-258","start_line":252,"end_line":258,"excerpt":"## luteolin-microbial-first-step\nGut bacteria can change the flavone scaffold.\nAnaerobic E. ramulus wK1 converted luteolin through an identified eriodictyol intermediate.\nModel: Resting bacterial cells, HPLC and mass spectrometry.\nLimitations: Human-derived strain, not a measured conversion fraction in a person.\nEvidence access: Primary abstract\nDegradation of quercetin and luteolin by Eubacterium ramulus. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11722907/ · DOI 10.1128/AEM.67.12.5558-5567.2001","model_system":"Resting bacterial cells, HPLC and mass spectrometry.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"26337a08-5cee-5cee-900e-e6d3e26ac6e4","stable_key":"import-22527305-af1f-536a-b419-7e73f08cc3ec","title":"Luteolin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"fd6ea0b1cef8d1c9965270494bfa815de14f679044f0b5d5d7bbf4904630ad76","revision_id":"c9a3dd80-c7e6-5fb4-bc91-8db265e7c8de","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}