{"id":"751ec871-7faf-5b97-86ec-0670acb388e5","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-male-mouse-lifespan","predicate":"increases","statement":"Daily oral ergothioneine at approximately 4-5 mg/kg from seven weeks of age extended lifespan in male mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"383f4e3f-1503-5b6d-8af3-8e3696dbdffe","mechanism_event_label":"An animal lifespan experiment supports further investigation.","subject":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"object":{"id":"fc09a422-cf8b-513f-90da-fc7839835d36","slug":"male-mouse-ergo-lifespan","display_name":"Male-mouse lifespan during lifelong ergothioneine exposure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"383f4e3f-1503-5b6d-8af3-8e3696dbdffe","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-male-mouse-lifespan-event","event_type":"observed_relationship","label":"An animal lifespan experiment supports further investigation.","description":"Daily oral ergothioneine at approximately 4-5 mg/kg from seven weeks of age extended lifespan in male mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"fc09a422-cf8b-513f-90da-fc7839835d36","slug":"male-mouse-ergo-lifespan","display_name":"Male-mouse lifespan during lifelong ergothioneine exposure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Male-mouse lifelong drinking-water exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not demonstrated human longevity or a human dose; sex and lifelong exposure matter.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"An animal lifespan experiment supports further investigation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Ergothioneine promotes longevity and healthy aging in male mice. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38446314/ · DOI 10.1007/s11357-024-01111-5","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"91eba992-4fab-5d48-abde-553bd61fb69f","evidence_kind":"source_excerpt","locator":"Lines 512-518","start_line":512,"end_line":518,"excerpt":"## ergothioneine-male-mouse-lifespan\nAn animal lifespan experiment supports further investigation.\nDaily oral ergothioneine at approximately 4-5 mg/kg from seven weeks of age extended lifespan in male mice.\nModel: Male-mouse lifelong drinking-water exposure.\nLimitations: Not demonstrated human longevity or a human dose; sex and lifelong exposure matter.\nEvidence access: Primary abstract\nErgothioneine promotes longevity and healthy aging in male mice. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38446314/ · DOI 10.1007/s11357-024-01111-5","model_system":"Male-mouse lifelong drinking-water exposure.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2f037d98-f3d0-5dbe-80d8-90b738f130d6","stable_key":"import-59b18080-c560-563d-abc5-bac4ee82a27c","title":"Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b6def8119f03cfabeec2fb55ba924340dc612e1dd42f05404201fa2b7ced5259","revision_id":"f88c38e6-ffb5-5a68-83ca-4610ca2c2df4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}