{"id":"74d8b441-dba0-5c94-8c84-bdef8c8e10be","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-menopause-recall","predicate":"depletion_impairs","statement":"Acute tryptophan depletion impaired delayed paragraph recall in a pilot of recently recovered menopausal women, without depressive relapse or significant mood worsening.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7e7623fe-6002-5476-b85e-9e42fda26fb5","mechanism_event_label":"Memory and mood did not respond identically.","subject":{"id":"769339cb-213b-559e-acc0-07ed00368b94","slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"},"object":{"id":"3b06e5a7-4ee3-5c6c-a815-55de7330927f","slug":"human-trp-depletion-recall","display_name":"Human delayed verbal recall during acute tryptophan depletion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7e7623fe-6002-5476-b85e-9e42fda26fb5","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-menopause-recall-event","event_type":"observed_relationship","label":"Memory and mood did not respond identically.","description":"Acute tryptophan depletion impaired delayed paragraph recall in a pilot of recently recovered menopausal women, without depressive relapse or significant mood worsening.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"769339cb-213b-559e-acc0-07ed00368b94","slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3b06e5a7-4ee3-5c6c-a815-55de7330927f","slug":"human-trp-depletion-recall","display_name":"Human delayed verbal recall during acute tryptophan depletion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human pilot after estradiol, fluoxetine or combined treatment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Different population and treatment context from the 1999 trial; no universal depletion response established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Tryptophan collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Memory and mood did not respond identically.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The resistance to depressive relapse in menopausal women undergoing tryptophan depletion: preliminary findings. · 2007 · https://pubmed.ncbi.nlm.nih.gov/16891341/ · DOI 10.1177/0269881106067330","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"6587ca10-be2f-512b-a1b0-f601b0f40815","evidence_kind":"source_excerpt","locator":"Lines 162-168","start_line":162,"end_line":168,"excerpt":"## tryptophan-menopause-recall\nMemory and mood did not respond identically.\nAcute tryptophan depletion impaired delayed paragraph recall in a pilot of recently recovered menopausal women, without depressive relapse or significant mood worsening.\nModel: Human pilot after estradiol, fluoxetine or combined treatment.\nLimitations: Different population and treatment context from the 1999 trial; no universal depletion response established.\nEvidence access: Primary abstract\nThe resistance to depressive relapse in menopausal women undergoing tryptophan depletion: preliminary findings. · 2007 · https://pubmed.ncbi.nlm.nih.gov/16891341/ · DOI 10.1177/0269881106067330","model_system":"Human pilot after estradiol, fluoxetine or combined treatment.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"73f9d3e7-fdc9-5418-8f3c-f4ef145f6efa","stable_key":"import-584c58f5-ab9f-53f3-97a9-55783db943b0","title":"Tryptophan: transport, protein synthesis, neuroactive metabolites, NAD and microbial pathways (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"7dfd20063b91900cb5c6ad675e3e675b7e25ef0fb8304eabac6f263cc5518284","revision_id":"bfafd789-fdf5-521f-bd28-c662e01ec1ea","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}