{"id":"74a1eba3-ed23-577f-acfd-f0e3bfa33a7e","stable_key":"475ea55a-65e9-51c3-a539-738a6a8f683f:mangiferin-trial-glucose-null","predicate":"no_detected_difference","statement":"Serum glucose did not differ significantly between groups.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"aa75de00-07c2-552a-b462-cd7902500245","mechanism_event_label":"The trial did not demonstrate improvement in every glucose endpoint.","subject":{"id":"2cfc0bd9-b5cc-58ab-852a-7705f3d8d47f","slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"},"object":{"id":"e4efb34e-ff1b-5f72-aacc-601c0e6ebafa","slug":"serum-glucose-concentration","display_name":"Serum glucose concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"aa75de00-07c2-552a-b462-cd7902500245","stable_key":"475ea55a-65e9-51c3-a539-738a6a8f683f:mangiferin-trial-glucose-null-event","event_type":"observed_intervention","label":"The trial did not demonstrate improvement in every glucose endpoint.","description":"Serum glucose did not differ significantly between groups.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2cfc0bd9-b5cc-58ab-852a-7705f3d8d47f","slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e4efb34e-ff1b-5f72-aacc-601c0e6ebafa","slug":"serum-glucose-concentration","display_name":"Serum glucose concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/mangiferin-research/25989216.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"2f57445ffe1eb20de3c2bf1170d152c358be1d7763cef2a091c0b3052040e539\", \"start_char\": 0, \"end_char\": 1522, \"text_sha256\": \"2f57445ffe1eb20de3c2bf1170d152c358be1d7763cef2a091c0b3052040e539\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Double-blind randomized placebo-controlled trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Mangiferin 150 mg/day for 12 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"One trial in a selected population; biomarkers do not demonstrate clinical outcomes or directly measure fatty-acid flux.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Mangiferin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Overweight adults with hyperlipidemia; 97 completers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The trial did not demonstrate improvement in every glucose endpoint.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mangiferin-p25989216] Mangiferin supplementation improves serum lipid profiles in overweight patients with hyperlipidemia: a double-blind randomized controlled trial. (2015). https://pubmed.ncbi.nlm.nih.gov/25989216/ DOI: 10.1038/srep10344","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Serum metabolic measurements","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8117092f-6483-573c-a041-3b2eeb2d7c69","evidence_kind":"source_excerpt","locator":"Lines 1251-1262","start_line":1251,"end_line":1262,"excerpt":"### mangiferin-trial-glucose-null\nSerum glucose did not differ significantly between groups.\nCondition category: normal\nnutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The trial did not demonstrate improvement in every glucose endpoint.\norganism: Overweight adults with hyperlipidemia; 97 completers\ntissue_or_cell_type: Serum metabolic measurements\nexperimental_model: Double-blind randomized placebo-controlled trial\nlimitations: One trial in a selected population; biomarkers do not demonstrate clinical outcomes or directly measure fatty-acid flux.\nexposure: Mangiferin 150 mg/day for 12 weeks\nevidence_span: {\"source_cache\": \"artifacts/mangiferin-research/25989216.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"2f57445ffe1eb20de3c2bf1170d152c358be1d7763cef2a091c0b3052040e539\", \"start_char\": 0, \"end_char\": 1522, \"text_sha256\": \"2f57445ffe1eb20de3c2bf1170d152c358be1d7763cef2a091c0b3052040e539\"}\n[mangiferin-p25989216] Mangiferin supplementation improves serum lipid profiles in overweight patients with hyperlipidemia: a double-blind randomized controlled trial. (2015). https://pubmed.ncbi.nlm.nih.gov/25989216/ DOI: 10.1038/srep10344","model_system":"Double-blind randomized placebo-controlled trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mangiferin-p25989216] Mangiferin supplementation improves serum lipid profiles in overweight patients with hyperlipidemia: a double-blind randomized controlled trial. (2015). https://pubmed.ncbi.nlm.nih.gov/25989216/ DOI: 10.1038/srep10344","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"267f942a-695a-5b62-a858-f71c06321ff5","stable_key":"import-475ea55a-65e9-51c3-a539-738a6a8f683f","title":"Mangiferin: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"295cb3a13742b3caeed19347ffcbc7863f5372d983da1625a942428919b4dc98","revision_id":"d9c2ee89-ff22-5e86-9d7f-7cb7e17f9ed2","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}