{"id":"749600c2-7a5b-587e-8bef-bfa5e7018d41","stable_key":"a8baf7e9-80e4-5d8c-adec-9a63e84d2f21:l-cysteine-pdac-coa-branch","predicate":"supports","statement":"System xc− inhibition lowered CoA and increased upstream pantothenate in the tested pancreatic cancer cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"eb2ec354-fcb8-5b4a-aacb-ff8079203d41","mechanism_event_label":"Vitamin B5 could accumulate while its downstream product fell because another substrate was missing.","subject":{"id":"aac19cc3-1b68-5ca3-a896-f61184f7320a","slug":"slc7a11","display_name":"SLC7A11","entity_type_key":"protein"},"object":{"id":"4faa6456-aff8-59eb-9e3f-3326a436e401","slug":"coenzyme-a","display_name":"Coenzyme A","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"eb2ec354-fcb8-5b4a-aacb-ff8079203d41","stable_key":"a8baf7e9-80e4-5d8c-adec-9a63e84d2f21:l-cysteine-pdac-coa-branch-event","event_type":"observed_relationship","label":"Vitamin B5 could accumulate while its downstream product fell because another substrate was missing.","description":"System xc− inhibition lowered CoA and increased upstream pantothenate in the tested pancreatic cancer cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"aac19cc3-1b68-5ca3-a896-f61184f7320a","slug":"slc7a11","display_name":"SLC7A11","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4faa6456-aff8-59eb-9e3f-3326a436e401","slug":"coenzyme-a","display_name":"Coenzyme A","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ca899f13-50ad-55e5-ab99-329ae0038c74","slug":"l-cysteine","display_name":"L-Cysteine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"cdd84f4d-3e8f-502a-a8c5-19672cc5346f","slug":"cystine","display_name":"Cystine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"7bc62072-9517-5563-a3b8-8c5ab64a464b","slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human PDAC cultures with cystine-import inhibition and metabolomics.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Pantothenate accumulation is not proof of B5 toxicity or a clinical biomarker threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Cysteine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-cysteine","display_name":"L-Cysteine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Vitamin B5 could accumulate while its downstream product fell because another substrate was missing.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Cysteine depletion induces pancreatic tumor ferroptosis in mice. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32241947/ · DOI 10.1126/science.aaw9872","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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