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It remains a recombinant model, not a measurement in a selenium-deficient animal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"hyperbaric-oxygen","display_name":"Hyperbaric oxygen therapy","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Rat enzyme in a bacterial expression host","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Without selenium the enzyme can no longer destroy peroxide at all.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[hbot-p10849437] Essential role of selenium in the catalytic activities of mammalian thioredoxin reductase revealed by characterization of recombinant enzymes with selenocysteine mutations. 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It remains a recombinant model, not a measurement in a selenium-deficient animal.\nexposure: SeCys498 replaced by cysteine or serine, and a truncated protein lacking the C-terminal SeCys-Gly dipeptide\nevidence_span: {\"source_cache\": \"artifacts/hbot-research/10849437.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"13fe79ebefbddac9a76f4cae2e0f1aede8d648b6568adca72f0b0a550e66bc90\", \"start_char\": 0, \"end_char\": 1374, \"text_sha256\": \"13fe79ebefbddac9a76f4cae2e0f1aede8d648b6568adca72f0b0a550e66bc90\"}\n[hbot-p10849437] Essential role of selenium in the catalytic activities of mammalian thioredoxin reductase revealed by characterization of recombinant enzymes with selenocysteine mutations. 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