{"id":"7456b977-ef2f-56b2-ba52-0f6dedab2ff9","stable_key":"475ea55a-65e9-51c3-a539-738a6a8f683f:mangiferin-sulfates","predicate":"metabolized_to","statement":"Norathyriol sulfates were prominent circulating conjugates after administration in rats.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7895b966-43d4-56ad-9b8f-deb3e0c81a96","mechanism_event_label":"Chemical conjugation changes what circulates; parent compound and conjugates remain separate.","subject":{"id":"d0f7f42a-ac45-5144-9ea5-a7586896cc6e","slug":"norathyriol","display_name":"Norathyriol","entity_type_key":"small_molecule"},"object":{"id":"05019bed-31b0-5e9b-a0aa-0e120b6f6b59","slug":"norathyriol-sulfates","display_name":"Norathyriol sulfate conjugates, positions unresolved","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"7895b966-43d4-56ad-9b8f-deb3e0c81a96","stable_key":"475ea55a-65e9-51c3-a539-738a6a8f683f:mangiferin-sulfates-event","event_type":"biochemical_relationship","label":"Chemical conjugation changes what circulates; parent compound and conjugates remain separate.","description":"Norathyriol sulfates were prominent circulating conjugates after administration in rats.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d0f7f42a-ac45-5144-9ea5-a7586896cc6e","slug":"norathyriol","display_name":"Norathyriol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"05019bed-31b0-5e9b-a0aa-0e120b6f6b59","slug":"norathyriol-sulfates","display_name":"Norathyriol sulfate conjugates, positions unresolved","entity_type_key":"chemical_species"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/mangiferin-research/30298742.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4caff8b6b7f04d6d1adca704cd53190801d3cf39f282bdb4e93b507a72b51288\", \"start_char\": 0, \"end_char\": 1196, \"text_sha256\": \"4caff8b6b7f04d6d1adca704cd53190801d3cf39f282bdb4e93b507a72b51288\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat pharmacokinetics and hepatocyte metabolite profiling","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Administered norathyriol; study-specific routes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Rat absolute bioavailability does not quantify human exposure or conversion from mangiferin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Mangiferin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rattus norvegicus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Chemical conjugation changes what circulates; parent compound and conjugates remain separate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mangiferin-p30298742] Absorption, Metabolism, and Pharmacokinetics Profiles of Norathyriol, an Aglycone of Mangiferin, in Rats by HPLC-MS/MS. (2018). https://pubmed.ncbi.nlm.nih.gov/30298742/ DOI: 10.1021/acs.jafc.8b03763","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Blood and hepatocytes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a07b4908-7420-5ee5-be18-23353765a4ee","evidence_kind":"source_excerpt","locator":"Lines 223-234","start_line":223,"end_line":234,"excerpt":"### mangiferin-sulfates\nNorathyriol sulfates were prominent circulating conjugates after administration in rats.\nCondition category: normal\nnutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Chemical conjugation changes what circulates; parent compound and conjugates remain separate.\norganism: Rattus norvegicus\ntissue_or_cell_type: Blood and hepatocytes\nexperimental_model: Rat pharmacokinetics and hepatocyte metabolite profiling\nlimitations: Rat absolute bioavailability does not quantify human exposure or conversion from mangiferin.\nexposure: Administered norathyriol; study-specific routes\nevidence_span: {\"source_cache\": \"artifacts/mangiferin-research/30298742.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4caff8b6b7f04d6d1adca704cd53190801d3cf39f282bdb4e93b507a72b51288\", \"start_char\": 0, \"end_char\": 1196, \"text_sha256\": \"4caff8b6b7f04d6d1adca704cd53190801d3cf39f282bdb4e93b507a72b51288\"}\n[mangiferin-p30298742] Absorption, Metabolism, and Pharmacokinetics Profiles of Norathyriol, an Aglycone of Mangiferin, in Rats by HPLC-MS/MS. (2018). https://pubmed.ncbi.nlm.nih.gov/30298742/ DOI: 10.1021/acs.jafc.8b03763","model_system":"Rat pharmacokinetics and hepatocyte metabolite profiling","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mangiferin-p30298742] Absorption, Metabolism, and Pharmacokinetics Profiles of Norathyriol, an Aglycone of Mangiferin, in Rats by HPLC-MS/MS. (2018). https://pubmed.ncbi.nlm.nih.gov/30298742/ DOI: 10.1021/acs.jafc.8b03763","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"267f942a-695a-5b62-a858-f71c06321ff5","stable_key":"import-475ea55a-65e9-51c3-a539-738a6a8f683f","title":"Mangiferin: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"295cb3a13742b3caeed19347ffcbc7863f5372d983da1625a942428919b4dc98","revision_id":"d9c2ee89-ff22-5e86-9d7f-7cb7e17f9ed2","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}