{"id":"74348d1e-25ff-5593-9509-ada2941bdf70","stable_key":"ca8e9e6a-6953-51ec-b712-2b06398a416d:ra-csf-detection","predicate":"reported_relationship","statement":"RA was below the stated CSF detection limit at the sampled trial visits.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"c4bd3272-80bb-5b1a-8ab7-076e75abcdeb","mechanism_event_label":"RA was below the stated CSF detection limit at the sampled trial visits.","subject":{"id":"2d483be1-dd8d-54e4-bac4-1a364bd1488a","slug":"lemon-balm-ra-enriched-extract","display_name":"RA-enriched Melissa officinalis extract","entity_type_key":"botanical"},"object":{"id":"6da1d199-55ff-5814-9c02-11842fbe7085","slug":"human-csf-ra","display_name":"RA concentration in sampled human CSF","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c4bd3272-80bb-5b1a-8ab7-076e75abcdeb","stable_key":"ca8e9e6a-6953-51ec-b712-2b06398a416d:ra-csf-detection-event","event_type":"experimental_observation","label":"RA was below the stated CSF detection limit at the sampled trial visits.","description":"### ra-csf-detection\n\nRA was below the stated CSF detection limit at the sampled trial visits.\nA negative sampled concentration is not proof of absent exposure at all earlier times.\nModel and exposure: Baseline and week 24; sampling generally 4–5 h after capsules; limit 0.0028 nM.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Safety and efficacy of Melissa officinalis extract containing rosmarinic acid in the prevention of Alzheimer's disease progression. | 2020 | https://pubmed.ncbi.nlm.nih.gov/33122694/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC7596544/ | https://doi.org/10.1038/s41598-020-73729-2 | Access: Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2d483be1-dd8d-54e4-bac4-1a364bd1488a","slug":"lemon-balm-ra-enriched-extract","display_name":"RA-enriched Melissa officinalis extract","entity_type_key":"botanical"},"role":"recorded factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"6da1d199-55ff-5814-9c02-11842fbe7085","slug":"human-csf-ra","display_name":"RA concentration in sampled human CSF","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"not_reported","sequence_order":1,"notes":""},{"entity":{"id":"6072a4ae-d563-5466-a1b2-6d280255d346","slug":"rosmarinic-acid","display_name":"Rosmarinic acid","entity_type_key":"small_molecule"},"role":"measured analyte","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Baseline and week 24; sampling generally 4–5 h after capsules; limit 0.0028 nM.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Recorded from source with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Rosmarinic acid collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"rosmarinic-acid","display_name":"Rosmarinic acid","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"RA was below the stated CSF detection limit at the sampled trial visits.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Safety and efficacy of Melissa officinalis extract containing rosmarinic acid in the prevention of Alzheimer's disease progression. | https://pubmed.ncbi.nlm.nih.gov/33122694/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC7596544/ | https://doi.org/10.1038/s41598-020-73729-2","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference ra-csf-detection; A negative sampled concentration is not proof of absent exposure at all earlier times.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8b2b635b-b828-561a-8fd7-5662ba9e407c","evidence_kind":"source_excerpt","locator":"Lines 465-471","start_line":465,"end_line":471,"excerpt":"### ra-csf-detection\n\nRA was below the stated CSF detection limit at the sampled trial visits.\nA negative sampled concentration is not proof of absent exposure at all earlier times.\nModel and exposure: Baseline and week 24; sampling generally 4–5 h after capsules; limit 0.0028 nM.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Safety and efficacy of Melissa officinalis extract containing rosmarinic acid in the prevention of Alzheimer's disease progression. | 2020 | https://pubmed.ncbi.nlm.nih.gov/33122694/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC7596544/ | https://doi.org/10.1038/s41598-020-73729-2 | Access: Primary full text: relevant Results/Methods and figure descriptions reviewed; supplements only where explicitly stated.","model_system":"Baseline and week 24; sampling generally 4–5 h after capsules; limit 0.0028 nM.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"606cff22-a6ed-59cd-a84d-87f44c59dc25","stable_key":"import-ca8e9e6a-6953-51ec-b712-2b06398a416d","title":"Rosmarinic acid: detailed mechanisms of action (reviewed 10 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed.","file_path":"","sha256":"684b4eab1dc2c0057f679109770af0de9340af5cd933377b590298cf8a752956","revision_id":"4028d9c5-fb17-54c5-b72c-c6d21678a832","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}