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(2010). https://pubmed.ncbi.nlm.nih.gov/20493882/ DOI: 10.1016/j.jmb.2010.05.034","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Purified enzyme","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"776cdc83-9d70-5e40-8fa3-fb8fd9277551","evidence_kind":"source_excerpt","locator":"Lines 374-385","start_line":374,"end_line":385,"excerpt":"### thc-faah-mechanism\nThe crystal structure of fatty acid amide hydrolase bound to URB597 revealed a deacylating water molecule and gave insight into how the enzyme is inactivated by carbamate inhibitors.\nCondition category: normal\nnutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates.\nplain_language: The structure shows exactly how the enzyme is jammed, down to a single water molecule.\norganism: Rat enzyme\ntissue_or_cell_type: Purified enzyme\nexperimental_model: Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597\nlimitations: Identifies the water molecule that explains why the inhibitor is slowly reversible. Rat enzyme structure.\nexposure: Inhibitor-bound structure\nevidence_span: {\"source_cache\": \"artifacts/thc-research/20493882.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c5acef9899dc5e90f996fb08c58b547c167bdbb2c879e1bd669a531fd10c3368\", \"start_char\": 0, \"end_char\": 1382, \"text_sha256\": \"c5acef9899dc5e90f996fb08c58b547c167bdbb2c879e1bd669a531fd10c3368\"}\n[thc-p20493882] Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation. (2010). https://pubmed.ncbi.nlm.nih.gov/20493882/ DOI: 10.1016/j.jmb.2010.05.034","model_system":"Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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