{"id":"73a5092d-4d3b-5974-99bb-b02fca81d017","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-primary-heart","predicate":"maintained","statement":"In a reported patient with homozygous SLC22A5-associated primary carnitine deficiency and a cardiac presentation, cardiac function remained normal during 14 years of oral carnitine treatment.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"06add57a-c4e7-51e2-a3fd-29efb711e43e","mechanism_event_label":"Treating a confirmed transport disorder can have a different role from general supplementation.","subject":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"object":{"id":"e05f27ab-113a-5523-a248-0d6510545873","slug":"human-primary-carnitine-cardiac-function","display_name":"Human cardiac function in primary carnitine deficiency","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"06add57a-c4e7-51e2-a3fd-29efb711e43e","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-primary-heart-event","event_type":"observed_relationship","label":"Treating a confirmed transport disorder can have a different role from general supplementation.","description":"In a reported patient with homozygous SLC22A5-associated primary carnitine deficiency and a cardiac presentation, cardiac function remained normal during 14 years of oral carnitine treatment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e05f27ab-113a-5523-a248-0d6510545873","slug":"human-primary-carnitine-cardiac-function","display_name":"Human cardiac function in primary carnitine deficiency","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"fb9ae9da-e4d3-5557-baac-d8b00e98ba10","slug":"slc22a5","display_name":"Human carnitine transporter OCTN2 / SLC22A5","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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