{"id":"739334ef-b37d-53f9-9c89-4d8f60f5a046","stable_key":"8c946991-97f0-55ee-8df0-00e67621962f:nad-plus-iv-metabolites","predicate":"increases","statement":"The six-hour NAD+ infusion altered circulating breakdown products and urinary NAD/metabolite excretion, demonstrating substantial handling of administered material.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6092b7c7-bbd2-5ee6-98ea-0ef0a79977e7","mechanism_event_label":"Some infused material is broken down or excreted.","subject":{"id":"35010247-8e1e-5ea0-ab54-f32b9956f825","slug":"human-intravenous-nad-intervention","display_name":"Intravenous NAD+ intervention in humans","entity_type_key":"cellular_process"},"object":{"id":"8792d060-c51b-5801-827d-48bc5261ed9c","slug":"human-iv-nad-catabolites","display_name":"Human NAD metabolites after intravenous NAD","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6092b7c7-bbd2-5ee6-98ea-0ef0a79977e7","stable_key":"8c946991-97f0-55ee-8df0-00e67621962f:nad-plus-iv-metabolites-event","event_type":"observed_relationship","label":"Some infused material is broken down or excreted.","description":"The six-hour NAD+ infusion altered circulating breakdown products and urinary NAD/metabolite excretion, demonstrating substantial handling of administered material.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"35010247-8e1e-5ea0-ab54-f32b9956f825","slug":"human-intravenous-nad-intervention","display_name":"Intravenous NAD+ intervention in humans","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8792d060-c51b-5801-827d-48bc5261ed9c","slug":"human-iv-nad-catabolites","display_name":"Human NAD metabolites after intravenous NAD","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"283ed24b-06a1-50aa-9281-df3bac6ce37e","slug":"nad-plus","display_name":"NAD+","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"08c27a3f-552e-5c92-8688-321a9b64a0d6","slug":"nicotinamide","display_name":"Nicotinamide","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"b02a63e0-a972-53c5-8a3a-eea6b7578cd5","slug":"n1-methylnicotinamide","display_name":"N1-Methylnicotinamide","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same 11-person human pilot.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a quantitative map of every tissue uptake route or evidence of rejuvenation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"NAD+ collection; 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