{"id":"734bf78c-2369-56a3-b64b-e2557a86aa7c","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-ign-loss","predicate":"abolishes","statement":"Mice deficient in intestinal gluconeogenesis lost the weight/glucose benefits of SCFA or soluble-fiber interventions despite similar microbial-composition changes.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8a9e4e0b-cf31-5560-9291-6b6c5cf38a73","mechanism_event_label":"Changing the microbiota was insufficient when a host pathway was missing.","subject":{"id":"bbb5e136-163e-5f5d-9fa0-29a80beb2756","slug":"mouse-ign-deficiency","display_name":"Mouse intestinal gluconeogenesis deficiency in the 2014 study","entity_type_key":"cellular_process"},"object":{"id":"de35ea06-901f-59d5-9fbb-1aed45b50642","slug":"mouse-butyrate-metabolic-benefit","display_name":"Mouse metabolic response to butyrate/fiber intervention","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8a9e4e0b-cf31-5560-9291-6b6c5cf38a73","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-ign-loss-event","event_type":"observed_relationship","label":"Changing the microbiota was insufficient when a host pathway was missing.","description":"Mice deficient in intestinal gluconeogenesis lost the weight/glucose benefits of SCFA or soluble-fiber interventions despite similar microbial-composition changes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"bbb5e136-163e-5f5d-9fa0-29a80beb2756","slug":"mouse-ign-deficiency","display_name":"Mouse intestinal gluconeogenesis deficiency in the 2014 study","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"de35ea06-901f-59d5-9fbb-1aed45b50642","slug":"mouse-butyrate-metabolic-benefit","display_name":"Mouse metabolic response to butyrate/fiber intervention","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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