{"id":"72e8182d-b769-55a9-a658-5322acd975d3","stable_key":"548ab9d6-3a9b-5bed-879c-17d03813b636:b2-maternal-milk-response","predicate":"increased_milk_riboflavin","statement":"Maternal supplementation increased breast-milk riboflavin and improved maternal status compared with placebo in the Gambian lactation trial.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"3358e5f0-c9ca-50f8-915a-c8e7da5f3fe2","mechanism_event_label":"The mother’s B2 supply affected the vitamin delivered in milk.","subject":{"id":"86eb1eee-a8d1-539c-8c17-0911f69b6f1b","slug":"riboflavin","display_name":"Riboflavin (vitamin B2)","entity_type_key":"small_molecule"},"object":{"id":"2c873cdc-eb26-596b-a96d-b212e1ef56a8","slug":"human-milk-riboflavin-concentration","display_name":"Human milk riboflavin concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3358e5f0-c9ca-50f8-915a-c8e7da5f3fe2","stable_key":"548ab9d6-3a9b-5bed-879c-17d03813b636:b2-maternal-milk-response-event","event_type":"observed_intervention","label":"The mother’s B2 supply affected the vitamin delivered in milk.","description":"Maternal supplementation increased breast-milk riboflavin and improved maternal status compared with placebo in the Gambian lactation trial.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"34eee5dc-1157-5374-8f5c-ce7ec87156a4","slug":"erythrocyte-glutathione-reductase-activation-coefficient","display_name":"Erythrocyte glutathione reductase activation coefficient / EGRAC","entity_type_key":"cellular_process"},"role":"maternal_status_measure","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"86eb1eee-a8d1-539c-8c17-0911f69b6f1b","slug":"riboflavin","display_name":"Riboflavin (vitamin B2)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2c873cdc-eb26-596b-a96d-b212e1ef56a8","slug":"human-milk-riboflavin-concentration","display_name":"Human milk riboflavin concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Double-blind controlled trial in 60 lactating women from two Gambian villages and their infants.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Maternal 2 mg/day riboflavin or placebo for 12 weeks; background intake about 0.5 mg/day; supplementation-withdrawal observations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Nutritionally constrained population; no direct mammary transporter assay in this trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Riboflavin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"riboflavin","display_name":"Riboflavin (vitamin B2)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The mother’s B2 supply affected the vitamin delivered in milk.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b2-bates1982] Riboflavin requirements of lactating Gambian women: a controlled supplementation trial (1982). https://pubmed.ncbi.nlm.nih.gov/7072623/ DOI: 10.1093/ajcn/35.4.701","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Maternal blood and human milk","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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Study references: [b2-bates1982] Riboflavin requirements of lactating Gambian women: a controlled supplementation trial (1982). https://pubmed.ncbi.nlm.nih.gov/7072623/ DOI: 10.1093/ajcn/35.4.701","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4f7c9578-82bf-5e2d-b5c4-72a79fb4f6af","stable_key":"import-548ab9d6-3a9b-5bed-879c-17d03813b636","title":"Riboflavin: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"680cb6bc8249877f2410f551807f10d390fdd719014137d7414ba3420e29228d","revision_id":"7a61e299-908d-5372-860b-99ed190f9d7a","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}