{"id":"727a5cee-d56f-5bbb-9390-e04a29024ef9","stable_key":"53d9b98d-e3a0-5416-bc88-adbe42a8cb1b:curcumin-mouse-ferritin","predicate":"reduces","statement":"Hepatic ferritin expression was suppressed.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3acae4ec-bec7-5c05-8fb2-6bf2e792e0a5","mechanism_event_label":"Expression of iron-storage machinery decreased.","subject":{"id":"0e625439-d093-5d1b-8713-dcfdafcf6811","slug":"curcumin","display_name":"Curcumin","entity_type_key":"small_molecule"},"object":{"id":"0cbd8677-8a58-566f-9c34-379e565406ff","slug":"mouse-hepatic-ferritin-expression","display_name":"Mouse hepatic ferritin expression","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3acae4ec-bec7-5c05-8fb2-6bf2e792e0a5","stable_key":"53d9b98d-e3a0-5416-bc88-adbe42a8cb1b:curcumin-mouse-ferritin-event","event_type":"biochemical_relationship","label":"Expression of iron-storage machinery decreased.","description":"Hepatic ferritin expression was suppressed.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0e625439-d093-5d1b-8713-dcfdafcf6811","slug":"curcumin","display_name":"Curcumin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0cbd8677-8a58-566f-9c34-379e565406ff","slug":"mouse-hepatic-ferritin-expression","display_name":"Mouse hepatic ferritin expression","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/curcumin-research/24634837.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3c64f5d7dd7206fa30f155d11ee68a90c72432b6ff1837922ee17ef1e811fec7\", \"start_char\": 0, \"end_char\": 1451, \"text_sha256\": \"3c64f5d7dd7206fa30f155d11ee68a90c72432b6ff1837922ee17ef1e811fec7\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Six-month feeding comparison in C57BL/6J mice","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Diet containing 0.2% curcumin versus unsupplemented diet","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Long-term mouse findings cannot be equated with acute human supplementation. Expression changes may be adaptive responses, not direct target binding.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Curcumin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"curcumin","display_name":"Curcumin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Expression of iron-storage machinery decreased.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[curcumin-p24634837] Curcumin may impair iron status when fed to mice for six months. (2014). https://pubmed.ncbi.nlm.nih.gov/24634837/ DOI: 10.1016/j.redox.2014.01.018","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Liver and spleen","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c70f8f31-359d-595f-97bf-ce33254e6db4","evidence_kind":"source_excerpt","locator":"Lines 671-682","start_line":671,"end_line":682,"excerpt":"### curcumin-mouse-ferritin\nHepatic ferritin expression was suppressed.\nCondition category: normal\nnutrient_topic: Curcumin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Expression of iron-storage machinery decreased.\norganism: Mus musculus\ntissue_or_cell_type: Liver and spleen\nexperimental_model: Six-month feeding comparison in C57BL/6J mice\nlimitations: Long-term mouse findings cannot be equated with acute human supplementation. Expression changes may be adaptive responses, not direct target binding.\nexposure: Diet containing 0.2% curcumin versus unsupplemented diet\nevidence_span: {\"source_cache\": \"artifacts/curcumin-research/24634837.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3c64f5d7dd7206fa30f155d11ee68a90c72432b6ff1837922ee17ef1e811fec7\", \"start_char\": 0, \"end_char\": 1451, \"text_sha256\": \"3c64f5d7dd7206fa30f155d11ee68a90c72432b6ff1837922ee17ef1e811fec7\"}\n[curcumin-p24634837] Curcumin may impair iron status when fed to mice for six months. (2014). https://pubmed.ncbi.nlm.nih.gov/24634837/ DOI: 10.1016/j.redox.2014.01.018","model_system":"Six-month feeding comparison in C57BL/6J mice","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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