{"id":"7278e027-3ba8-5c4d-8962-ea3677da42c4","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:nattokinase-does-not-change-srebf1","predicate":"does_not_change_expression_of","statement":"SREBF1 messenger RNA appeared in the sequencing screen but was unaffected on Q-PCR confirmation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"ecc37319-72a7-57c2-9c81-c5021266d5f4","mechanism_event_label":"SREBF1 messenger RNA appeared in the sequencing screen but was unaffected on Q-PCR confirmation.","subject":{"id":"6b03a125-209a-5060-8b35-ec9e0e54033c","slug":"nattokinase","display_name":"Nattokinase / subtilisin NAT","entity_type_key":"peptide"},"object":{"id":"278d2aa8-ed70-58ab-8650-3d9b32f725b5","slug":"srebf1","display_name":"Sterol regulatory element-binding protein 1 / SREBP-1","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"ecc37319-72a7-57c2-9c81-c5021266d5f4","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:nattokinase-does-not-change-srebf1-event","event_type":"biochemical_relationship","label":"SREBF1 messenger RNA appeared in the sequencing screen but was unaffected on Q-PCR confirmation.","description":"Cultured endothelium, transcriptional profiling","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6b03a125-209a-5060-8b35-ec9e0e54033c","slug":"nattokinase","display_name":"Nattokinase / subtilisin NAT","entity_type_key":"peptide"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"278d2aa8-ed70-58ab-8650-3d9b32f725b5","slug":"srebf1","display_name":"Sterol regulatory element-binding protein 1 / SREBP-1","entity_type_key":"protein"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. 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