{"id":"71d6472c-eaac-579f-a05c-55b341c4acae","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-act-ergosterol-photoconversion","predicate":"photoconverts_to","statement":"Ultraviolet irradiation of white button mushrooms generated previtamin D2 from ergosterol, identified by chromatographic analysis.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"998d12dc-221d-53a5-b698-ae3df7761b45","mechanism_event_label":"UV converts a fungal sterol into the precursor of vitamin D2.","subject":{"id":"d46b3722-7b3b-5993-8e70-61af43a0ee98","slug":"ergosterol","display_name":"Ergosterol","entity_type_key":"small_molecule"},"object":{"id":"b295beaf-0771-5f43-91bf-2c9ac30704a4","slug":"previtamin-d2","display_name":"Previtamin D2","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"998d12dc-221d-53a5-b698-ae3df7761b45","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-act-ergosterol-photoconversion-event","event_type":"biochemical_relationship","label":"UV converts a fungal sterol into the precursor of vitamin D2.","description":"Ultraviolet irradiation of white button mushrooms generated previtamin D2 from ergosterol, identified by chromatographic analysis.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d46b3722-7b3b-5993-8e70-61af43a0ee98","slug":"ergosterol","display_name":"Ergosterol","entity_type_key":"small_molecule"},"role":"substrate","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b295beaf-0771-5f43-91bf-2c9ac30704a4","slug":"previtamin-d2","display_name":"Previtamin D2","entity_type_key":"small_molecule"},"role":"product","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary Results: Photoproduction of previtamin D2 and its conversion to vitamin D2; Figures 2-5.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"White button mushroom and ergosterol photochemistry","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"UV-irradiated preparations; protocol varied with irradiation experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This is fungal/ex-vivo photochemistry; human skin D3 photochemistry is a separate route.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient","value_text":"Vitamin D2 and D3","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-d","display_name":"Vitamin D2 and D3","entity_type_key":"chemical_species"}},{"dimension":"nutrient_topic","value_text":"Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-d","display_name":"Vitamin D2 and D3","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Agaricus bisporus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"UV converts a fungal sterol into the precursor of vitamin D2.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[keegan2013] Photobiology of vitamin D in mushrooms and its bioavailability in humans. (2013). https://pubmed.ncbi.nlm.nih.gov/24494050/ DOI: 10.4161/derm.23321","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"mushroom tissue","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6e1954da-7942-5f85-bfbe-c753c2a012f2","evidence_kind":"source_excerpt","locator":"Lines 136-149","start_line":136,"end_line":149,"excerpt":"### vd-act-ergosterol-photoconversion\nUltraviolet irradiation of white button mushrooms generated previtamin D2 from ergosterol, identified by chromatographic analysis.\nCondition category: normal\nnutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: UV converts a fungal sterol into the precursor of vitamin D2.\norganism: Agaricus bisporus\ntissue_or_cell_type: mushroom tissue\nexperimental_model: White button mushroom and ergosterol photochemistry\nlimitations: This is fungal/ex-vivo photochemistry; human skin D3 photochemistry is a separate route.\nexposure: UV-irradiated preparations; protocol varied with irradiation experiment.\ncross_nutrient: false\nevidence_location: Primary Results: Photoproduction of previtamin D2 and its conversion to vitamin D2; Figures 2-5.\nnutrient: Vitamin D2 and D3\n[keegan2013] Photobiology of vitamin D in mushrooms and its bioavailability in humans. 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