{"id":"71bf82e1-ea9a-5c00-9210-eabeb2913b43","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-bio-pank2-species-localization","predicate":"differs_in_localization_from","statement":"Human PANK2 was mitochondrial whereas mouse Pank2 localized to the cytosol in the comparative study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2ceda38b-7c4b-5f15-bd1d-9ac0ab35d11e","mechanism_event_label":"The mouse Pank2 model differs from humans in where the enzyme resides.","subject":{"id":"496571a5-06f5-5aa5-b95b-aae8b6556c7f","slug":"pank2","display_name":"Human pantothenate kinase 2 / PANK2","entity_type_key":"protein"},"object":{"id":"6fb79c92-00bd-5c79-8dd0-04abae16e954","slug":"mouse-pank2","display_name":"Mouse pantothenate kinase 2 / Pank2","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"2ceda38b-7c4b-5f15-bd1d-9ac0ab35d11e","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-bio-pank2-species-localization-event","event_type":"biochemical_relationship","label":"The mouse Pank2 model differs from humans in where the enzyme resides.","description":"Human PANK2 was mitochondrial whereas mouse Pank2 localized to the cytosol in the comparative study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"496571a5-06f5-5aa5-b95b-aae8b6556c7f","slug":"pank2","display_name":"Human pantothenate kinase 2 / PANK2","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6fb79c92-00bd-5c79-8dd0-04abae16e954","slug":"mouse-pank2","display_name":"Mouse pantothenate kinase 2 / Pank2","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Comparative human and mouse PANK2 biochemistry and cellular localization","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Comparative localization of human and mouse proteins; exact constructs/cell lines not extracted.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Localization difference must be retained when translating mouse knockout or rescue findings; this claim does not assign human PANK2 to a particular mitochondrial subcompartment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens and Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The mouse Pank2 model differs from humans in where the enzyme resides.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b5-bio-pank2mouse] Localization and regulation of mouse pantothenate kinase 2. (2007). https://pubmed.ncbi.nlm.nih.gov/17825826/ DOI: 10.1016/j.febslet.2007.08.056","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Cellular subcellular-localization experiments","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"abca1f9d-45e5-53fb-b24d-701eefaf628e","evidence_kind":"source_excerpt","locator":"Lines 639-650","start_line":639,"end_line":650,"excerpt":"### b5-bio-pank2-species-localization\nHuman PANK2 was mitochondrial whereas mouse Pank2 localized to the cytosol in the comparative study.\nCondition category: normal\nnutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The mouse Pank2 model differs from humans in where the enzyme resides.\norganism: Homo sapiens and Mus musculus\ntissue_or_cell_type: Cellular subcellular-localization experiments\nexperimental_model: Comparative human and mouse PANK2 biochemistry and cellular localization\nlimitations: Localization difference must be retained when translating mouse knockout or rescue findings; this claim does not assign human PANK2 to a particular mitochondrial subcompartment.\nexposure: Comparative localization of human and mouse proteins; exact constructs/cell lines not extracted.\ncross_nutrient: false\n[b5-bio-pank2mouse] Localization and regulation of mouse pantothenate kinase 2. (2007). https://pubmed.ncbi.nlm.nih.gov/17825826/ DOI: 10.1016/j.febslet.2007.08.056","model_system":"Comparative human and mouse PANK2 biochemistry and cellular localization","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b5-bio-pank2mouse] Localization and regulation of mouse pantothenate kinase 2. (2007). https://pubmed.ncbi.nlm.nih.gov/17825826/ DOI: 10.1016/j.febslet.2007.08.056","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0716b500-dd0b-5425-b9d0-d88bc9c09e86","stable_key":"import-f992b796-377d-53bf-a39b-7e5d41dbe194","title":"Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b5a49f5a2373ca6064c9a4e014e052dad2f6f199a82bb09b26b82b831c36110b","revision_id":"78f3e793-f084-5ee2-8703-b661c4b650bf","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}