{"id":"71a45db2-fa36-53d1-bf57-babae0d8a847","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-serotonergic-interaction","predicate":"increases_risk","statement":"Serotonergic co-medication can increase serotonin-syndrome risk with lithium.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f9c29c75-bf0c-50ac-9287-fa95207f0c50","mechanism_event_label":"A signaling interaction differs from a clearance interaction.","subject":{"id":"78dbdeea-7853-51e4-94e0-efd5ec806a33","slug":"concurrent-serotonergic-drug-exposure","display_name":"Concurrent serotonergic-drug exposure","entity_type_key":"cellular_process"},"object":{"id":"443bbece-fd70-5b09-92af-546d0db3479b","slug":"human-lithium-serotonin-syndrome","display_name":"Serotonin-syndrome risk during lithium coexposure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f9c29c75-bf0c-50ac-9287-fa95207f0c50","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-serotonergic-interaction-event","event_type":"observed_relationship","label":"A signaling interaction differs from a clearance interaction.","description":"Serotonergic co-medication can increase serotonin-syndrome risk with lithium.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"78dbdeea-7853-51e4-94e0-efd5ec806a33","slug":"concurrent-serotonergic-drug-exposure","display_name":"Concurrent serotonergic-drug exposure","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"443bbece-fd70-5b09-92af-546d0db3479b","slug":"human-lithium-serotonin-syndrome","display_name":"Serotonin-syndrome risk during lithium coexposure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Official prescribing information","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Official prescribing information, sections 5, 7 and 12; updated 2026-07-06, prescribing text revised 2023-06.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Regulatory clinical statement; not an experiment resolving a single molecular target. 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