{"id":"71170ead-6035-531f-a3b9-d1a4bb349df6","stable_key":"cb41aa31-e26b-5b60-b7e0-e4985fb7aea8:hydroxytyrosol-food-matrix","predicate":"increases_early_exposure_to","statement":"With the same 5 mg hydroxytyrosol dose, extra-virgin olive oil produced higher 30-minute plasma hydroxytyrosol and greater urinary recovery than control in a 20-person double-blind study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"81db79b3-66ba-5b94-85a2-36347be3bc2b","mechanism_event_label":"With the same 5 mg hydroxytyrosol dose, extra-virgin olive oil produced higher 30-minute plasma hydroxytyrosol and greater urinary recovery than control in a 20-person double-blind study.","subject":{"id":"585dc8bf-cc6e-5852-8fd2-b55570ac61e4","slug":"extra-virgin-olive-oil","display_name":"Extra-virgin olive oil","entity_type_key":"botanical"},"object":{"id":"45a7aaec-8acc-5d5a-a014-c483ef5385e2","slug":"hydroxytyrosol","display_name":"Hydroxytyrosol","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"81db79b3-66ba-5b94-85a2-36347be3bc2b","stable_key":"cb41aa31-e26b-5b60-b7e0-e4985fb7aea8:hydroxytyrosol-food-matrix-event","event_type":"observed_relationship","label":"With the same 5 mg hydroxytyrosol dose, extra-virgin olive oil produced higher 30-minute plasma hydroxytyrosol and greater urinary recovery than control in a 20-person double-blind study.","description":"With the same 5 mg hydroxytyrosol dose, extra-virgin olive oil produced higher 30-minute plasma hydroxytyrosol and greater urinary recovery than control in a 20-person double-blind study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"585dc8bf-cc6e-5852-8fd2-b55570ac61e4","slug":"extra-virgin-olive-oil","display_name":"Extra-virgin olive oil","entity_type_key":"botanical"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"45a7aaec-8acc-5d5a-a014-c483ef5385e2","slug":"hydroxytyrosol","display_name":"Hydroxytyrosol","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"5 mg hydroxytyrosol in different food matrices","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Early plasma and urine sampling","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Twenty human volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Matrix effects do not establish superior clinical outcomes and may reflect absorption, metabolism, or analytical recovery.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Hydroxytyrosol chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"hydroxytyrosol","display_name":"Hydroxytyrosol","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Twenty human volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"With the same 5 mg hydroxytyrosol dose, extra-virgin olive oil produced higher 30-minute plasma hydroxytyrosol and greater urinary recovery than control in a 20-person double-blind study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Pharmacokinetics and bioavailability of hydroxytyrosol are dependent on the food matrix in humans. (2021). https://pubmed.ncbi.nlm.nih.gov/32524230/ DOI: 10.1007/s00394-020-02295-0","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Plasma and urinary hydroxytyrosol/metabolite pharmacokinetics","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6e9f4616-7f3b-5b1d-a787-8e2282cf4890","evidence_kind":"source_excerpt","locator":"Lines 22-31","start_line":22,"end_line":31,"excerpt":"## hydroxytyrosol-food-matrix\nWith the same 5 mg hydroxytyrosol dose, extra-virgin olive oil produced higher 30-minute plasma hydroxytyrosol and greater urinary recovery than control in a 20-person double-blind study.\nModel/species: Twenty human volunteers\nTissue/system: Plasma and urinary hydroxytyrosol/metabolite pharmacokinetics\nExposure: 5 mg hydroxytyrosol in different food matrices\nRoute: Oral\nDuration: Early plasma and urine sampling\nLimits: Matrix effects do not establish superior clinical outcomes and may reflect absorption, metabolism, or analytical recovery.\nPrimary reference: Pharmacokinetics and bioavailability of hydroxytyrosol are dependent on the food matrix in humans. (2021). https://pubmed.ncbi.nlm.nih.gov/32524230/ DOI: 10.1007/s00394-020-02295-0\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Twenty human volunteers","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"f83cd982-34f0-55d4-8563-eedfb0f009f2","stable_key":"import-cb41aa31-e26b-5b60-b7e0-e4985fb7aea8","title":"Hydroxytyrosol: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text.","file_path":"","sha256":"7677fedffc16af238fc1ace3f88d206dd42b29b163c40b6e69ba6ed2457a3aee","revision_id":"1e0bd617-6834-5a2d-a74e-c058967d99b7","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}