{"id":"7102a253-6f52-5c57-a068-733bbc9b7131","stable_key":"b26c9d01-98fd-50d3-8f39-44db46961ee5:acetate-vinegar-worsens-gastroparesis","predicate":"reduces","statement":"In patients with type 1 diabetes and diabetic gastroparesis the median gastric emptying rate was 27% without vinegar and 17% with vinegar, a statistically significant reduction, and the authors concluded this might be a disadvantage for their glycaemic control.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"20d6de8d-793f-5c15-b30c-eef31df544de","mechanism_event_label":"In people whose stomachs already empty too slowly, vinegar made that worse.","subject":{"id":"698adb48-4b27-586e-88b2-0619c6d34529","slug":"apple-cider-vinegar","display_name":"Apple cider vinegar as used in the type 1 diabetes trial","entity_type_key":"chemical_species"},"object":{"id":"1bccaa6a-27de-508b-bf06-9486510923f8","slug":"antral-cross-sectional-area","display_name":"Gastric emptying rate measured as the change in antral cross-sectional area by real-time ultrasonography","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"20d6de8d-793f-5c15-b30c-eef31df544de","stable_key":"b26c9d01-98fd-50d3-8f39-44db46961ee5:acetate-vinegar-worsens-gastroparesis-event","event_type":"observed_intervention","label":"In people whose stomachs already empty too slowly, vinegar made that worse.","description":"In patients with type 1 diabetes and diabetic gastroparesis the median gastric emptying rate was 27% without vinegar and 17% with vinegar, a statistically significant reduction, and the authors concluded this might be a disadvantage for their glycaemic control.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d81e012c-f55c-5782-a718-158b66778fb8","slug":"diabetic-gastroparesis","display_name":"Diabetic gastroparesis","entity_type_key":"cellular_process"},"role":"existing_condition","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"698adb48-4b27-586e-88b2-0619c6d34529","slug":"apple-cider-vinegar","display_name":"Apple cider vinegar as used in the type 1 diabetes trial","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"1bccaa6a-27de-508b-bf06-9486510923f8","slug":"antral-cross-sectional-area","display_name":"Gastric emptying rate measured as the change in antral cross-sectional area by real-time ultrasonography","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/acetate-research/18093343.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"092c8db0cd31e510e21838bd5ad6cc16876368af06584a2fc6d44efa2e189439\", \"start_char\": 0, \"end_char\": 1477, \"text_sha256\": \"092c8db0cd31e510e21838bd5ad6cc16876368af06584a2fc6d44efa2e189439\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Investigator-blinded crossover in ten patients with type 1 diabetes and diabetic gastroparesis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"30 ml apple cider vinegar in 200 ml water daily before breakfast for two weeks, with gastric emptying measured by standardised real-time ultrasonography after 300 g rice pudding","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Ten patients, one of whom had undergone vagotomy. It is recorded because the same mechanism that is read as a benefit in healthy people is unwanted in people whose stomachs already empty too slowly.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Acetic acid research collection; topical membership is not evidence of a direct clinical effect, and the ingested acid is recorded separately from the circulating acetate anion.","comparator":null,"unit":null,"notes":"","entity":{"slug":"acetic-acid","display_name":"Acetic acid","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"In people whose stomachs already empty too slowly, vinegar made that worse.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[acetate-p18093343] Effect of apple cider vinegar on delayed gastric emptying in patients with type 1 diabetes mellitus: a pilot study. (2007). https://pubmed.ncbi.nlm.nih.gov/18093343/ DOI: 10.1186/1471-230x-7-46","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Stomach","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"cf7c2dea-af1d-59b7-9797-c5e142deddb4","evidence_kind":"source_excerpt","locator":"Lines 186-197","start_line":186,"end_line":197,"excerpt":"### acetate-vinegar-worsens-gastroparesis\nIn patients with type 1 diabetes and diabetic gastroparesis the median gastric emptying rate was 27% without vinegar and 17% with vinegar, a statistically significant reduction, and the authors concluded this might be a disadvantage for their glycaemic control.\nCondition category: biomarker_context\nnutrient_topic: Acetic acid research collection; topical membership is not evidence of a direct clinical effect, and the ingested acid is recorded separately from the circulating acetate anion.\nplain_language: In people whose stomachs already empty too slowly, vinegar made that worse.\norganism: Human\ntissue_or_cell_type: Stomach\nexperimental_model: Investigator-blinded crossover in ten patients with type 1 diabetes and diabetic gastroparesis\nlimitations: Ten patients, one of whom had undergone vagotomy. It is recorded because the same mechanism that is read as a benefit in healthy people is unwanted in people whose stomachs already empty too slowly.\nexposure: 30 ml apple cider vinegar in 200 ml water daily before breakfast for two weeks, with gastric emptying measured by standardised real-time ultrasonography after 300 g rice pudding\nevidence_span: {\"source_cache\": \"artifacts/acetate-research/18093343.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"092c8db0cd31e510e21838bd5ad6cc16876368af06584a2fc6d44efa2e189439\", \"start_char\": 0, \"end_char\": 1477, \"text_sha256\": \"092c8db0cd31e510e21838bd5ad6cc16876368af06584a2fc6d44efa2e189439\"}\n[acetate-p18093343] Effect of apple cider vinegar on delayed gastric emptying in patients with type 1 diabetes mellitus: a pilot study. (2007). https://pubmed.ncbi.nlm.nih.gov/18093343/ DOI: 10.1186/1471-230x-7-46","model_system":"Investigator-blinded crossover in ten patients with type 1 diabetes and diabetic gastroparesis","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [acetate-p18093343] Effect of apple cider vinegar on delayed gastric emptying in patients with type 1 diabetes mellitus: a pilot study. (2007). https://pubmed.ncbi.nlm.nih.gov/18093343/ DOI: 10.1186/1471-230x-7-46","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"8356baaf-173c-5549-80cd-bbbb2007ffb5","stable_key":"import-b26c9d01-98fd-50d3-8f39-44db46961ee5","title":"Acetic acid: the ingested acid, the receptors acetate binds, the acetyl-CoA it becomes, and the acetyl groups that reach histones (2026-09-21)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"1441d249b16db25c0d488407e5cc881222acffc2f16af88cb3197d9d5697bccc","revision_id":"9bfeb605-f589-5e99-84b9-e56968a3bc1f","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}