{"id":"7096cb59-3335-5773-9a65-bb535aa3281a","stable_key":"182336c6-ed36-5ec6-8a09-25c31096262e:dim-psa-change","predicate":"associated_with_decrease_in","statement":"PSA declined in 71% of evaluable patients during the preoperative study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9cb6277f-7cb3-5146-95da-d7385a03787d","mechanism_event_label":"An uncontrolled marker change cannot establish cancer prevention or treatment benefit.","subject":{"id":"6009bdd4-f1b5-5867-b5c3-cdf7c9645cd0","slug":"dim","display_name":"3,3'-Diindolylmethane / DIM","entity_type_key":"small_molecule"},"object":{"id":"7346b3ab-5d46-5cc1-b940-98aa68d647bf","slug":"serum-psa","display_name":"Serum prostate-specific antigen","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9cb6277f-7cb3-5146-95da-d7385a03787d","stable_key":"182336c6-ed36-5ec6-8a09-25c31096262e:dim-psa-change-event","event_type":"observed_intervention","label":"An uncontrolled marker change cannot establish cancer prevention or treatment benefit.","description":"PSA declined in 71% of evaluable patients during the preoperative study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6009bdd4-f1b5-5867-b5c3-cdf7c9645cd0","slug":"dim","display_name":"3,3'-Diindolylmethane / DIM","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7346b3ab-5d46-5cc1-b940-98aa68d647bf","slug":"serum-psa","display_name":"Serum prostate-specific antigen","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/dim-research/27069550.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7048d2f449ad8c31af0eb9e89b956d9d1dcebb0f74e1a4d0eabcc3635314053e\", \"start_char\": 0, \"end_char\": 1626, \"text_sha256\": \"7048d2f449ad8c31af0eb9e89b956d9d1dcebb0f74e1a4d0eabcc3635314053e\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Pre-prostatectomy tissue and biomarker study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Absorption-enhanced DIM 225 mg twice daily for at least 14 days","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Uncontrolled preoperative study. Tissue detection and altered localization do not establish tumor control, survival benefit or testosterone lowering.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"dim","display_name":"3,3'-Diindolylmethane / DIM","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"28 evaluable men with localized prostate cancer","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"An uncontrolled marker change cannot establish cancer prevention or treatment benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[dim-p27069550] Anti-androgenic activity of absorption-enhanced 3, 3'-diindolylmethane in prostatectomy patients. (2016). https://pubmed.ncbi.nlm.nih.gov/27069550/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Prostate DIM, androgen-receptor localization and PSA","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"97034a48-b147-54f6-bd7a-58e204e73858","evidence_kind":"source_excerpt","locator":"Lines 1156-1167","start_line":1156,"end_line":1167,"excerpt":"### dim-psa-change\nPSA declined in 71% of evaluable patients during the preoperative study.\nCondition category: normal\nnutrient_topic: Diindolylmethane (DIM) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: An uncontrolled marker change cannot establish cancer prevention or treatment benefit.\norganism: 28 evaluable men with localized prostate cancer\ntissue_or_cell_type: Prostate DIM, androgen-receptor localization and PSA\nexperimental_model: Pre-prostatectomy tissue and biomarker study\nlimitations: Uncontrolled preoperative study. Tissue detection and altered localization do not establish tumor control, survival benefit or testosterone lowering.\nexposure: Absorption-enhanced DIM 225 mg twice daily for at least 14 days\nevidence_span: {\"source_cache\": \"artifacts/dim-research/27069550.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7048d2f449ad8c31af0eb9e89b956d9d1dcebb0f74e1a4d0eabcc3635314053e\", \"start_char\": 0, \"end_char\": 1626, \"text_sha256\": \"7048d2f449ad8c31af0eb9e89b956d9d1dcebb0f74e1a4d0eabcc3635314053e\"}\n[dim-p27069550] Anti-androgenic activity of absorption-enhanced 3, 3'-diindolylmethane in prostatectomy patients. (2016). https://pubmed.ncbi.nlm.nih.gov/27069550/","model_system":"Pre-prostatectomy tissue and biomarker study","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [dim-p27069550] Anti-androgenic activity of absorption-enhanced 3, 3'-diindolylmethane in prostatectomy patients. (2016). https://pubmed.ncbi.nlm.nih.gov/27069550/","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b6d70682-97f9-5893-a03c-f9f88836033c","stable_key":"import-182336c6-ed36-5ec6-8a09-25c31096262e","title":"Diindolylmethane (DIM): formation, receptor signaling, metabolism and drug interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"31e14060de904976d2f5d439f2bc9c8a99a72d34626c562c78429025e050d404","revision_id":"611094c1-a9cf-5b9b-b255-ac70b571696a","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}