{"id":"707ca0f4-0775-54cf-a694-c7dec0e74ecf","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-bilayer-dynamics","predicate":"shows","statement":"Molecular-dynamics simulations found membrane-associated astaxanthin could contact either bilayer surface one at a time, while aqueous molecules aggregated and did not spontaneously insert within the simulated conditions.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"55485112-e2c4-5447-bb87-a0f423de7212","mechanism_event_label":"The modeled molecule moved within the membrane rather than acting as a fixed bridge.","subject":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"84bc5c0f-1fa3-57ab-b99c-a00f6a9d0f8c","slug":"astaxanthin-bilayer-dynamics","display_name":"Astaxanthin dynamics in a simulated lipid bilayer","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"55485112-e2c4-5447-bb87-a0f423de7212","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-bilayer-dynamics-event","event_type":"observed_relationship","label":"The modeled molecule moved within the membrane rather than acting as a fixed bridge.","description":"Molecular-dynamics simulations found membrane-associated astaxanthin could contact either bilayer surface one at a time, while aqueous molecules aggregated and did not spontaneously insert within the simulated conditions.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"84bc5c0f-1fa3-57ab-b99c-a00f6a9d0f8c","slug":"astaxanthin-bilayer-dynamics","display_name":"Astaxanthin dynamics in a simulated lipid bilayer","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Computational lipid-bilayer simulations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Model composition, timescale and starting state limit inference; this does not determine all biological membrane orientations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The modeled molecule moved within the membrane rather than acting as a fixed bridge.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Location and dynamics of astaxanthin in the membrane. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40523462/ · DOI 10.1016/j.chemphyslip.2025.105512","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"64ede82a-884d-5fd9-b154-c109c385943d","evidence_kind":"source_excerpt","locator":"Lines 182-188","start_line":182,"end_line":188,"excerpt":"## astaxanthin-bilayer-dynamics\nThe modeled molecule moved within the membrane rather than acting as a fixed bridge.\nMolecular-dynamics simulations found membrane-associated astaxanthin could contact either bilayer surface one at a time, while aqueous molecules aggregated and did not spontaneously insert within the simulated conditions.\nModel: Computational lipid-bilayer simulations.\nLimitations: Model composition, timescale and starting state limit inference; this does not determine all biological membrane orientations.\nEvidence access: Primary abstract\nLocation and dynamics of astaxanthin in the membrane. · 2025 · https://pubmed.ncbi.nlm.nih.gov/40523462/ · DOI 10.1016/j.chemphyslip.2025.105512","model_system":"Computational lipid-bilayer simulations.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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