{"id":"70198bc6-7a61-5182-bebe-2d01955d0604","stable_key":"792249b7-a38d-5f43-afb6-2936818a3fa2:tartrazine-aspirin-histology","predicate":"attenuates_dye_associated_damage","statement":"Aspirin pretreatment and co-exposure attenuated the brain histological injury observed with high-dose tartrazine.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"9b435c7a-3326-55cc-b0ce-88248848a0eb","mechanism_event_label":"Aspirin pretreatment and co-exposure attenuated the brain histological injury observed with high-dose tartrazine.","subject":{"id":"8ac405bf-3ea0-539a-8e5e-abf503dc7081","slug":"aspirin","display_name":"Aspirin / acetylsalicylic acid","entity_type_key":"drug"},"object":{"id":"8218c6c4-4d2e-579e-bf9a-30c253d1fc2a","slug":"rat-tartrazine-brain-histopathology","display_name":"Brain histopathology in high-dose tartrazine-exposed rats","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9b435c7a-3326-55cc-b0ce-88248848a0eb","stable_key":"792249b7-a38d-5f43-afb6-2936818a3fa2:tartrazine-aspirin-histology-event","event_type":"observed_relationship","label":"Aspirin pretreatment and co-exposure attenuated the brain histological injury observed with high-dose tartrazine.","description":"Aspirin pretreatment and co-exposure attenuated the brain histological injury observed with high-dose tartrazine.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8ac405bf-3ea0-539a-8e5e-abf503dc7081","slug":"aspirin","display_name":"Aspirin / acetylsalicylic acid","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8218c6c4-4d2e-579e-bf9a-30c253d1fc2a","slug":"rat-tartrazine-brain-histopathology","display_name":"Brain histopathology in high-dose tartrazine-exposed rats","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"135b5f4d-0c59-5359-a645-39796e820d42","slug":"tartrazine","display_name":"Tartrazine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Aspirin 150 mg/kg body weight for 3 weeks, starting one week before tartrazine 700 mg/kg for 2 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"3 weeks total; 2 weeks co-exposure","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary full-text methods/results and metadata.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; source-specific experimental curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Male Wistar rats; six per group","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"High-dose preclinical experiment, not an aspirin treatment recommendation. The routes differ and the study does not establish antioxidant or p53 mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Tartrazine food-colorant chapter; nutrient, drug and peptide interactions retain their models and limits.","comparator":null,"unit":null,"notes":"","entity":{"slug":"tartrazine","display_name":"Tartrazine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Male Wistar rats; six per group","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Aspirin pretreatment and co-exposure attenuated the brain histological injury observed with high-dose tartrazine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"High-Dose Aspirin Reverses Tartrazine-Induced Cell Growth Dysregulation Independent of p53 Signaling and Antioxidant Mechanisms in Rat Brain. (2019). https://pubmed.ncbi.nlm.nih.gov/31032366/ DOI: 10.1155/2019/9096404","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Intraperitoneal aspirin plus oral tartrazine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Brain histopathology","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"50fa1734-a730-509f-9e59-ded5aefd7427","evidence_kind":"source_excerpt","locator":"Lines 391-400","start_line":391,"end_line":400,"excerpt":"## tartrazine-aspirin-histology\nAspirin pretreatment and co-exposure attenuated the brain histological injury observed with high-dose tartrazine.\nModel/species: Male Wistar rats; six per group\nTissue: Brain histopathology\nExposure: Aspirin 150 mg/kg body weight for 3 weeks, starting one week before tartrazine 700 mg/kg for 2 weeks\nRoute: Intraperitoneal aspirin plus oral tartrazine\nDuration: 3 weeks total; 2 weeks co-exposure\nLimits: High-dose preclinical experiment, not an aspirin treatment recommendation. The routes differ and the study does not establish antioxidant or p53 mediation.\nPrimary reference: High-Dose Aspirin Reverses Tartrazine-Induced Cell Growth Dysregulation Independent of p53 Signaling and Antioxidant Mechanisms in Rat Brain. (2019). https://pubmed.ncbi.nlm.nih.gov/31032366/ DOI: 10.1155/2019/9096404\nAccess: Primary full-text methods/results and metadata.","model_system":"Male Wistar rats; six per group","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span, not a publisher quotation; primary citation retained.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d9540941-68b4-5a0d-a5c1-828665a918e2","stable_key":"import-792249b7-a38d-5f43-afb6-2936818a3fa2","title":"Tartrazine: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of eighteen primary studies. 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