{"id":"70117b86-3bd7-51c3-8a36-3a3b307269e0","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-human-brain-association","predicate":"associated_with_redistribution","statement":"Human brain analyses found lithium enrichment in amyloid plaques and lower non-plaque lithium associated with cognition.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6f9fef8e-4f7f-5718-aba5-ce3fb8d8d23e","mechanism_event_label":"Where lithium is located may matter more than a total measurement.","subject":{"id":"6d150746-6ba9-50e6-b886-879b6e34b14f","slug":"human-ad-amyloid-plaque-compartment","display_name":"Human AD/MCI amyloid-plaque compartment","entity_type_key":"cellular_process"},"object":{"id":"813e7a06-f068-5ae8-87d7-e9c6a8dd59bc","slug":"human-nonplaque-cortical-lithium","display_name":"Human non-plaque cortical lithium measurement","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6f9fef8e-4f7f-5718-aba5-ce3fb8d8d23e","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-human-brain-association-event","event_type":"observed_relationship","label":"Where lithium is located may matter more than a total measurement.","description":"Human brain analyses found lithium enrichment in amyloid plaques and lower non-plaque lithium associated with cognition.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6d150746-6ba9-50e6-b886-879b6e34b14f","slug":"human-ad-amyloid-plaque-compartment","display_name":"Human AD/MCI amyloid-plaque compartment","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"813e7a06-f068-5ae8-87d7-e9c6a8dd59bc","slug":"human-nonplaque-cortical-lithium","display_name":"Human non-plaque cortical lithium measurement","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; 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