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Without glucose, production capacity declined and the GSH/GSSG balance shifted despite conserved total glutathione equivalents. This is a resource-dependent ex vivo observation. NADPH production through the pentose-phosphate pathway was a proposed explanation, not a selective G6PD perturbation or proof of a B2-dependent clinical response. 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Without glucose, production capacity declined and the GSH/GSSG balance shifted despite conserved total glutathione equivalents. This is a resource-dependent ex vivo observation. NADPH production through the pentose-phosphate pathway was a proposed explanation, not a selective G6PD perturbation or proof of a B2-dependent clinical response. [Benavides 2007](https://pmc.ncbi.nlm.nih.gov/articles/PMC2084282/)","model_system":"Isolated human RBCs, oxygen-controlled/anoxic assay, repeated garlic additions with or without 10 mM glucose.","directness":"reported_statement","verification_status":"source_recorded","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. 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