{"id":"6f3c32a5-08e7-5ded-8c35-54205518b04f","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-mouse-trpv3-loss","predicate":"deletion_prevents","statement":"Trpv3-knockout mouse eggs failed to conduct Sr2+ or undergo strontium-induced activation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7f177acc-e9d5-5193-af06-06c7ba9a7c58","mechanism_event_label":"Removing the channel removes the experimental response.","subject":{"id":"733f3820-01cf-5f49-9d54-f784d20e2697","slug":"mouse-trpv3","display_name":"Mouse TRPV3","entity_type_key":"protein"},"object":{"id":"099356f4-ab04-54d5-b3a8-eb92f9f7068e","slug":"mouse-strontium-egg-activation","display_name":"Strontium-induced mouse egg activation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7f177acc-e9d5-5193-af06-06c7ba9a7c58","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-mouse-trpv3-loss-event","event_type":"observed_relationship","label":"Removing the channel removes the experimental response.","description":"Trpv3-knockout mouse eggs failed to conduct Sr2+ or undergo strontium-induced activation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"733f3820-01cf-5f49-9d54-f784d20e2697","slug":"mouse-trpv3","display_name":"Mouse TRPV3","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"099356f4-ab04-54d5-b3a8-eb92f9f7068e","slug":"mouse-strontium-egg-activation","display_name":"Strontium-induced mouse egg activation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2ca2864b-1ef0-54e4-8397-1dbe7207a0d2","slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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