{"id":"6f050aa7-df34-540d-bdf8-5a36f21809fc","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-plasma-isomer","predicate":"preferentially_appears_in","statement":"After three men consumed 100 mg astaxanthin with a meal, 13Z astaxanthin was selectively enriched in plasma relative to the administered mixture.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2bc23ce7-3559-59fd-b38a-5b83d3595239","mechanism_event_label":"Blood composition did not simply copy the swallowed isomer mixture.","subject":{"id":"be0b148a-7020-59b8-9f1c-c6c30492929c","slug":"13z-astaxanthin","display_name":"13Z astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"c2729ba2-b40a-5df6-85c6-d38eaaa2910f","slug":"human-astaxanthin-exposure","display_name":"Human circulating astaxanthin exposure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2bc23ce7-3559-59fd-b38a-5b83d3595239","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-plasma-isomer-event","event_type":"observed_relationship","label":"Blood composition did not simply copy the swallowed isomer mixture.","description":"After three men consumed 100 mg astaxanthin with a meal, 13Z astaxanthin was selectively enriched in plasma relative to the administered mixture.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"be0b148a-7020-59b8-9f1c-c6c30492929c","slug":"13z-astaxanthin","display_name":"13Z astaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c2729ba2-b40a-5df6-85c6-d38eaaa2910f","slug":"human-astaxanthin-exposure","display_name":"Human circulating astaxanthin exposure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e5a53562-0048-521a-9314-e157c7225fd3","slug":"all-e-astaxanthin","display_name":"All-E astaxanthin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"65ec3f99-1845-5f37-bcc7-5b68912ac772","slug":"9z-astaxanthin","display_name":"9Z astaxanthin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Three-person single-dose pharmacokinetic study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small sample and unusually high dose; selective appearance does not alone identify absorption versus clearance.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Blood composition did not simply copy the swallowed isomer mixture.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Plasma appearance and distribution of astaxanthin E/Z and R/S isomers in plasma lipoproteins of men after single dose administration of astaxanthin. · 2000 · https://pubmed.ncbi.nlm.nih.gov/11120445/ · DOI 10.1016/s0955-2863(00)00104-2","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4da0c70b-48df-5e96-8518-5e0ec19db0a9","evidence_kind":"source_excerpt","locator":"Lines 70-76","start_line":70,"end_line":76,"excerpt":"## astaxanthin-plasma-isomer\nBlood composition did not simply copy the swallowed isomer mixture.\nAfter three men consumed 100 mg astaxanthin with a meal, 13Z astaxanthin was selectively enriched in plasma relative to the administered mixture.\nModel: Three-person single-dose pharmacokinetic study.\nLimitations: Small sample and unusually high dose; selective appearance does not alone identify absorption versus clearance.\nEvidence access: Primary abstract\nPlasma appearance and distribution of astaxanthin E/Z and R/S isomers in plasma lipoproteins of men after single dose administration of astaxanthin. · 2000 · https://pubmed.ncbi.nlm.nih.gov/11120445/ · DOI 10.1016/s0955-2863(00)00104-2","model_system":"Three-person single-dose pharmacokinetic study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"98640e32f62e6c0387578165342ad21b3d2325701fcfdbb5c48886c783040e5e","revision_id":"a82757ce-1feb-582c-a5fc-f7de36308f1f","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}