{"id":"6ea38be9-5969-5d4d-a03f-e2e1a0d6ea57","stable_key":"507ed066-fd6d-5722-9223-97b66302e7e3:glycine-glycine-withdrawal","predicate":"reduces_tested","statement":"Removing extracellular glycine alone slowed LOX IMVI proliferation but did not impair A498 cells in the same study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8a53d91a-1a86-5df0-9145-325cf0035290","mechanism_event_label":"Some cells depend more on imported glycine than others.","subject":{"id":"4055f99e-77bb-5337-a5cf-cd879ffcddcb","slug":"glycine-free-culture-medium","display_name":"Glycine-free culture medium","entity_type_key":"cellular_process"},"object":{"id":"aef7f96b-34da-5b69-97bb-21c946058fc2","slug":"human-lox-imvi-proliferation","display_name":"Human LOX IMVI cell proliferation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8a53d91a-1a86-5df0-9145-325cf0035290","stable_key":"507ed066-fd6d-5722-9223-97b66302e7e3:glycine-glycine-withdrawal-event","event_type":"observed_relationship","label":"Some cells depend more on imported glycine than others.","description":"Removing extracellular glycine alone slowed LOX IMVI proliferation but did not impair A498 cells in the same study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4055f99e-77bb-5337-a5cf-cd879ffcddcb","slug":"glycine-free-culture-medium","display_name":"Glycine-free culture medium","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"aef7f96b-34da-5b69-97bb-21c946058fc2","slug":"human-lox-imvi-proliferation","display_name":"Human LOX IMVI cell proliferation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2b507258-430c-51fe-9fd2-e510c2c197a9","slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human cancer-cell comparison under culture glycine withdrawal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A local experimental shortage, not a universal human dietary deficiency threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Glycine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Some cells depend more on imported glycine than others.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22628656/ · DOI 10.1126/science.1218595","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"956a34ba-9fbf-5898-ae7d-a4f88763c5ef","evidence_kind":"source_excerpt","locator":"Lines 162-168","start_line":162,"end_line":168,"excerpt":"## glycine-glycine-withdrawal\nSome cells depend more on imported glycine than others.\nRemoving extracellular glycine alone slowed LOX IMVI proliferation but did not impair A498 cells in the same study.\nModel: Human cancer-cell comparison under culture glycine withdrawal.\nLimitations: A local experimental shortage, not a universal human dietary deficiency threshold.\nEvidence access: Primary full text\nMetabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22628656/ · DOI 10.1126/science.1218595","model_system":"Human cancer-cell comparison under culture glycine withdrawal.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7b2859d8-e2bf-51e7-8e32-0715c10cbc49","stable_key":"import-507ed066-fd6d-5722-9223-97b66302e7e3","title":"Glycine: supply, one-carbon allocation, receptors and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"4fabd2fc8e71ca156c91023e7340be3f5a02ae03e91d3a24b231c2adfb0de0aa","revision_id":"24801e49-34a8-53c3-bdf5-b59143441450","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}