{"id":"6e8c3330-db39-579a-a96a-82e7b9668962","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-skin-tumor-model","predicate":"reduces","statement":"Resveratrol inhibited tumorigenesis in the reported mouse-skin model and preneoplastic lesions in carcinogen-treated mouse mammary glands in culture.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"41495efd-1e9d-5d04-a090-0d6cf5318fab","mechanism_event_label":"Preclinical disease models are preserved without becoming human treatment claims.","subject":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"object":{"id":"282ca87b-00f9-5290-8fd2-0395cb1ef665","slug":"mouse-resveratrol-skin-tumorigenesis","display_name":"Mouse skin tumorigenesis during resveratrol treatment","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"41495efd-1e9d-5d04-a090-0d6cf5318fab","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-skin-tumor-model-event","event_type":"observed_relationship","label":"Preclinical disease models are preserved without becoming human treatment claims.","description":"Resveratrol inhibited tumorigenesis in the reported mouse-skin model and preneoplastic lesions in carcinogen-treated mouse mammary glands in culture.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"282ca87b-00f9-5290-8fd2-0395cb1ef665","slug":"mouse-resveratrol-skin-tumorigenesis","display_name":"Mouse skin tumorigenesis during resveratrol treatment","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse skin and organ-culture assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No human efficacy estimate follows.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Preclinical disease models are preserved without becoming human treatment claims.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. · 1997 · https://pubmed.ncbi.nlm.nih.gov/8985016/ · DOI 10.1126/science.275.5297.218","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ed4d823b-bb14-5de4-b93a-ae85c28d6940","evidence_kind":"source_excerpt","locator":"Lines 534-540","start_line":534,"end_line":540,"excerpt":"## resveratrol-skin-tumor-model\nPreclinical disease models are preserved without becoming human treatment claims.\nResveratrol inhibited tumorigenesis in the reported mouse-skin model and preneoplastic lesions in carcinogen-treated mouse mammary glands in culture.\nModel: Mouse skin and organ-culture assays.\nLimitations: No human efficacy estimate follows.\nEvidence access: Primary abstract\nCancer chemopreventive activity of resveratrol, a natural product derived from grapes. · 1997 · https://pubmed.ncbi.nlm.nih.gov/8985016/ · DOI 10.1126/science.275.5297.218","model_system":"Mouse skin and organ-culture assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"04885b4bee72f912a7f3f618f1b2bf79c944dbcb20500398c2729fc8228dcd9a","revision_id":"99504ff2-f1d3-5f4c-bc31-e1030d27a918","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}