{"id":"6e6aefc7-3cdd-5672-a57b-989d4e95bb5c","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-microbiome-null","predicate":"did_not_broadly_change","statement":"Five drops of stevia twice daily for 12 weeks produced no significant alpha- or beta-diversity change or clear taxon abundance differences in 14 users versus 13 controls; a classifier distinguished groups with about 75% accuracy.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"cc85c98d-cba1-5e4c-bf25-581ab0bd8406","mechanism_event_label":"A negative broad-community comparison does not mean every microbial feature is unchanged.","subject":{"id":"c78086c3-7657-589b-b353-1691df2d9f8f","slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"},"object":{"id":"59e015e4-bc52-5a6f-a9fb-2a58373d4c25","slug":"human-stevia-12week-microbiota","display_name":"Human 12-week stevia gut-community composition","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"cc85c98d-cba1-5e4c-bf25-581ab0bd8406","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-microbiome-null-event","event_type":"observed_relationship","label":"A negative broad-community comparison does not mean every microbial feature is unchanged.","description":"Five drops of stevia twice daily for 12 weeks produced no significant alpha- or beta-diversity change or clear taxon abundance differences in 14 users versus 13 controls; a classifier distinguished groups with about 75% accuracy.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c78086c3-7657-589b-b353-1691df2d9f8f","slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"59e015e4-bc52-5a6f-a9fb-2a58373d4c25","slug":"human-stevia-12week-microbiota","display_name":"Human 12-week stevia gut-community composition","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Healthy normal-BMI adults; fecal 16S profiling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small study; drop volume and formulation constrain generalization. Classification alone is not proof of a causal or harmful microbiome change.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A negative broad-community comparison does not mean every microbial feature is unchanged.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Consumption of the Non-Nutritive Sweetener Stevia for 12 Weeks Does Not Alter the Composition of the Human Gut Microbiota. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38257188/ · DOI 10.3390/nu16020296","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"62c9f232-bec0-5d0d-861e-df66091d1891","evidence_kind":"source_excerpt","locator":"Lines 402-408","start_line":402,"end_line":408,"excerpt":"## stevia-microbiome-null\nA negative broad-community comparison does not mean every microbial feature is unchanged.\nFive drops of stevia twice daily for 12 weeks produced no significant alpha- or beta-diversity change or clear taxon abundance differences in 14 users versus 13 controls; a classifier distinguished groups with about 75% accuracy.\nModel: Healthy normal-BMI adults; fecal 16S profiling.\nLimitations: Small study; drop volume and formulation constrain generalization. Classification alone is not proof of a causal or harmful microbiome change.\nEvidence access: Primary abstract\nConsumption of the Non-Nutritive Sweetener Stevia for 12 Weeks Does Not Alter the Composition of the Human Gut Microbiota. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38257188/ · DOI 10.3390/nu16020296","model_system":"Healthy normal-BMI adults; fecal 16S profiling.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"295304c9-609c-5b05-a18f-a00ab7b965ed","stable_key":"import-6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7","title":"Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"a36a82c2f8a0a971ea43e9e742db65f45848d13ab77310c0dd6b5cd55e31fc16","revision_id":"ea0355af-a926-511a-a7f2-1750baa95a8d","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}