{"id":"6e1ebc5d-2c78-5ad9-b336-c62b5d79f8b7","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-acetate-carbon","predicate":"supplies_carbon_to","statement":"Isotope tracing showed external acetate supplied 85–90% of butyrate carbon in the tested F. prausnitzii and Roseburia cultures supplied with 60 mM acetate and 10 mM glucose.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9a53f31d-ad0e-55c4-acd3-9bd0949c34fd","mechanism_event_label":"One bacterium’s fermentation product can become another product’s carbon source.","subject":{"id":"e366e758-1fb0-5573-aed1-34f6df874ac7","slug":"acetate","display_name":"Acetate","entity_type_key":"small_molecule"},"object":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"9a53f31d-ad0e-55c4-acd3-9bd0949c34fd","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-acetate-carbon-event","event_type":"observed_relationship","label":"One bacterium’s fermentation product can become another product’s carbon source.","description":"Isotope tracing showed external acetate supplied 85–90% of butyrate carbon in the tested F. prausnitzii and Roseburia cultures supplied with 60 mM acetate and 10 mM glucose.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e366e758-1fb0-5573-aed1-34f6df874ac7","slug":"acetate","display_name":"Acetate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b7ed6e4c-e560-5cee-b68f-895f21862e6f","slug":"acetyl-coa","display_name":"Acetyl-CoA","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human-fecal bacterial isolates and 13C-acetate tracing.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This culture fraction is not a universal human conversion percentage.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"One bacterium’s fermentation product can become another product’s carbon source.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Contribution of acetate to butyrate formation by human faecal bacteria. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15182395/ · DOI 10.1079/BJN20041150","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"081fe894-93d3-55c3-be55-538f3d5fdaa1","evidence_kind":"source_excerpt","locator":"Lines 54-60","start_line":54,"end_line":60,"excerpt":"## butyrate-acetate-carbon\nOne bacterium’s fermentation product can become another product’s carbon source.\nIsotope tracing showed external acetate supplied 85–90% of butyrate carbon in the tested F. prausnitzii and Roseburia cultures supplied with 60 mM acetate and 10 mM glucose.\nModel: Human-fecal bacterial isolates and 13C-acetate tracing.\nLimitations: This culture fraction is not a universal human conversion percentage.\nEvidence access: Primary abstract\nContribution of acetate to butyrate formation by human faecal bacteria. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15182395/ · DOI 10.1079/BJN20041150","model_system":"Human-fecal bacterial isolates and 13C-acetate tracing.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"33205bb8-dcbe-5d2c-afca-86075d7748d1","stable_key":"import-104835a3-b891-5dc4-a6bb-42ab7c6f96c4","title":"Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"a1253eb4426fc45d7b7c113028aa4ba2e9f89a9653272f3795437fc222bad558","revision_id":"c2320e65-a252-57a9-8838-7abf3d23400e","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}