{"id":"6de3eec7-74e0-5515-899e-5413d2f998d1","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-chamomile-insomnia-null","predicate":"no_detected_change_in_recorded_comparison","statement":"Chamomile did not significantly improve total sleep time, sleep efficiency or the other reported sleep-diary outcomes.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"36b15739-6634-5660-9748-81524740edea","mechanism_event_label":"Chamomile did not significantly improve total sleep time, sleep efficiency or the other reported sleep-diary outcomes.","subject":{"id":"79b3c42b-a3d9-5cb4-92dd-d13cd50966e5","slug":"chamomile-extract-insomnia-2011","display_name":"Chamomile extract in the 2011 insomnia trial","entity_type_key":"botanical"},"object":{"id":"aa141558-eb7f-5f91-b385-031e8db5e472","slug":"api-human-insomnia-diary","display_name":"Sleep-diary outcomes in the 2011 chamomile trial","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"36b15739-6634-5660-9748-81524740edea","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-chamomile-insomnia-null-event","event_type":"experimental_observation","label":"Chamomile did not significantly improve total sleep time, sleep efficiency or the other reported sleep-diary outcomes.","description":"### api-chamomile-insomnia-null\n\nChamomile did not significantly improve total sleep time, sleep efficiency or the other reported sleep-diary outcomes.\nA small extract trial cannot establish that purified apigenin is an effective hypnotic.\nModel and exposure: 34 adults; 270 mg extract twice daily, 28 days.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study. | 2011 | https://pubmed.ncbi.nlm.nih.gov/21939549/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC3198755/ | https://doi.org/10.1186/1472-6882-11-78 | Access: Indexed primary abstract reviewed; full text located but not used to extract additional methods. The exact tested preparation remains the actor.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"79b3c42b-a3d9-5cb4-92dd-d13cd50966e5","slug":"chamomile-extract-insomnia-2011","display_name":"Chamomile extract in the 2011 insomnia trial","entity_type_key":"botanical"},"role":"tested factor","stoichiometry":null,"state_label":"Chamomile extract","sequence_order":0,"notes":""},{"entity":{"id":"aa141558-eb7f-5f91-b385-031e8db5e472","slug":"api-human-insomnia-diary","display_name":"Sleep-diary outcomes in the 2011 chamomile trial","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"no_detected_change","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Indexed primary abstract reviewed; full text located but not used to extract additional methods. The exact tested preparation remains the actor.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Chamomile extract\", \"comparator\": \"Placebo\", \"endpoint\": \"Chamomile did not significantly improve total sleep time, sleep efficiency or the other reported sleep-diary outcomes.\", \"effect_direction\": \"no_detected_change\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; recorded from source.","entity":null},{"dimension":"experimental_model","value_text":"34 adults; 270 mg extract twice daily, 28 days.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Recorded from source with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Apigenin collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Chamomile did not significantly improve total sleep time, sleep efficiency or the other reported sleep-diary outcomes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study. | https://pubmed.ncbi.nlm.nih.gov/21939549/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC3198755/ | https://doi.org/10.1186/1472-6882-11-78","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference api-chamomile-insomnia-null; A small extract trial cannot establish that purified apigenin is an effective hypnotic.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cdb318b5-d3be-57d6-83b1-10a68f209062","evidence_kind":"source_excerpt","locator":"Lines 836-842","start_line":836,"end_line":842,"excerpt":"### api-chamomile-insomnia-null\n\nChamomile did not significantly improve total sleep time, sleep efficiency or the other reported sleep-diary outcomes.\nA small extract trial cannot establish that purified apigenin is an effective hypnotic.\nModel and exposure: 34 adults; 270 mg extract twice daily, 28 days.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study. | 2011 | https://pubmed.ncbi.nlm.nih.gov/21939549/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC3198755/ | https://doi.org/10.1186/1472-6882-11-78 | Access: Indexed primary abstract reviewed; full text located but not used to extract additional methods. The exact tested preparation remains the actor.","model_system":"34 adults; 270 mg extract twice daily, 28 days.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"54eac90b-add1-5f56-9036-d900307c5697","stable_key":"import-ff370329-68a3-573d-96ee-597de78a3967","title":"Apigenin: detailed mechanisms of action (reviewed 10 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed.","file_path":"","sha256":"ede6e5c6b91d66b66844f2ff667a7f8303d9ac1281f15dc09db703f7de4da942","revision_id":"b41a39a2-0197-549c-97a5-1765e6696931","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}