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topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"RAR signaling helps cultured airway cells adopt a mucus-producing program.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[va-koo-1999] Role of retinoid receptors in the regulation of mucin gene expression by retinoic acid in human tracheobronchial epithelial cells (1999). https://pubmed.ncbi.nlm.nih.gov/10024510/ DOI: 10.1042/bj3380351","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Normal tracheobronchial epithelial cells","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"85478458-b7d8-5c42-b164-df88c0ba89b9","evidence_kind":"source_excerpt","locator":"Lines 1357-1368","start_line":1357,"end_line":1368,"excerpt":"### va-sig-rara-airway-mucin\nRAR alpha-selective pharmacology supported RAR alpha-mediated induction of airway mucin transcripts, including MUC5AC.\nCondition category: normal\nnutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: RAR signaling helps cultured airway cells adopt a mucus-producing program.\norganism: Homo sapiens\ntissue_or_cell_type: Normal tracheobronchial epithelial cells\nexperimental_model: Normal human tracheobronchial epithelial cultures with receptor-selective agonists/antagonists.\nlimitations: Transcript changes do not establish improved mucus clearance.\nevidence_locator: Abstract\nexposure: Receptor-selective agonists/antagonists\n[va-koo-1999] Role of retinoid receptors in the regulation of mucin gene expression by retinoic acid in human tracheobronchial epithelial cells (1999). https://pubmed.ncbi.nlm.nih.gov/10024510/ DOI: 10.1042/bj3380351","model_system":"Normal human tracheobronchial epithelial cultures with receptor-selective agonists/antagonists.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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