{"id":"6d54aa93-68c1-53d8-b6d9-2f6186bb9177","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-pku-carrier-kinetics","predicate":"has_greater_response_in_carriers","statement":"After 34 mg/kg, twelve female PKU heterozygotes had higher peak phenylalanine than ten noncarrier females, 15.1 versus 8.95 micromol/dL.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"bc3c0c53-b232-5568-b93e-7ea5f09ebc54","mechanism_event_label":"Reduced metabolic reserve can change the response to a precursor source.","subject":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"object":{"id":"53c53d5a-5af6-5901-ba09-bccf1f416178","slug":"human-plasma-phenylalanine","display_name":"Human plasma phenylalanine concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"bc3c0c53-b232-5568-b93e-7ea5f09ebc54","stable_key":"b428117d-3a8c-5e74-8711-168153e19545:aspartame-pku-carrier-kinetics-event","event_type":"observed_relationship","label":"Reduced metabolic reserve can change the response to a precursor source.","description":"After 34 mg/kg, twelve female PKU heterozygotes had higher peak phenylalanine than ten noncarrier females, 15.1 versus 8.95 micromol/dL.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"53c53d5a-5af6-5901-ba09-bccf1f416178","slug":"human-plasma-phenylalanine","display_name":"Human plasma phenylalanine concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"190407ad-0219-54b5-b05f-7c75f3895ca6","slug":"l-phenylalanine","display_name":"L-Phenylalanine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"ea908671-6f85-5342-abe4-1a466a3b0572","slug":"pah","display_name":"Human phenylalanine hydroxylase / PAH","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human carrier comparison, also including twelve noncarrier men.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Heterozygotes do not represent patients with biallelic PAH deficiency; the damaged male-baseline sentence in indexed abstract is not reconstructed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Aspartame collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Reduced metabolic reserve can change the response to a precursor source.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Plasma phenylalanine levels in phenylketonuric heterozygous and normal adults administered aspartame at 34 mg/kg body weight. · 1981 · https://pubmed.ncbi.nlm.nih.gov/7268794/ · DOI 10.1016/0300-483x(81)90108-6","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"aa6c8409-977a-53a5-9072-0f5df423b93a","evidence_kind":"source_excerpt","locator":"Lines 146-152","start_line":146,"end_line":152,"excerpt":"## aspartame-pku-carrier-kinetics\nReduced metabolic reserve can change the response to a precursor source.\nAfter 34 mg/kg, twelve female PKU heterozygotes had higher peak phenylalanine than ten noncarrier females, 15.1 versus 8.95 micromol/dL.\nModel: Human carrier comparison, also including twelve noncarrier men.\nLimitations: Heterozygotes do not represent patients with biallelic PAH deficiency; the damaged male-baseline sentence in indexed abstract is not reconstructed.\nEvidence access: Primary abstract\nPlasma phenylalanine levels in phenylketonuric heterozygous and normal adults administered aspartame at 34 mg/kg body weight. · 1981 · https://pubmed.ncbi.nlm.nih.gov/7268794/ · DOI 10.1016/0300-483x(81)90108-6","model_system":"Human carrier comparison, also including twelve noncarrier men.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2bba7d36-993f-5ba7-acaf-2e4d573527ed","stable_key":"import-b428117d-3a8c-5e74-8711-168153e19545","title":"Aspartame: digestion, taste, metabolite dependencies and experimental signaling (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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