{"id":"6d257b2f-07d4-59cc-892d-4646c7bec157","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iodine-syn-escape-hormone-recovery","predicate":"produces_time_dependent_change","statement":"During continued 0.05% NaI exposure, rat serum T4 and T3 fell at day 1 but returned to normal by day 6.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"bbec6f83-a14a-5aa7-827a-b281249102b4","mechanism_event_label":"The initial hormone suppression wore off despite continued high iodide exposure.","subject":{"id":"e886c46c-651f-5e31-a875-9665c20a2e13","slug":"sodium-iodide","display_name":"Sodium iodide","entity_type_key":"chemical_species"},"object":{"id":"9b8cccf8-2844-5179-a1f2-64f834675911","slug":"rat-serum-thyroid-hormones","display_name":"Rat serum thyroid hormones","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"bbec6f83-a14a-5aa7-827a-b281249102b4","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iodine-syn-escape-hormone-recovery-event","event_type":"observed_intervention","label":"The initial hormone suppression wore off despite continued high iodide exposure.","description":"During continued 0.05% NaI exposure, rat serum T4 and T3 fell at day 1 but returned to normal by day 6.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"83b11ca6-52c7-5a1b-8c39-d9cdf89244e3","slug":"iodide","display_name":"Iodide ion","entity_type_key":"ion"},"role":"excess_anion","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f2b25f38-ec94-57d0-a46d-dd0fee45f01e","slug":"thyroxine","display_name":"T4","entity_type_key":"small_molecule"},"role":"measured_hormone","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"559f37d2-ee0a-589b-8689-fa80ca9ae653","slug":"triiodothyronine","display_name":"T3","entity_type_key":"small_molecule"},"role":"measured_hormone","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"acfbc5ec-b299-5365-8c5d-9e492c18d1d9","slug":"rat-slc5a5","display_name":"Rat sodium/iodide symporter / Slc5a5","entity_type_key":"protein"},"role":"parallel_expression_measurement","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"e886c46c-651f-5e31-a875-9665c20a2e13","slug":"sodium-iodide","display_name":"Sodium iodide","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"9b8cccf8-2844-5179-a1f2-64f834675911","slug":"rat-serum-thyroid-hormones","display_name":"Rat serum thyroid hormones","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/iodine-synthesis-sources/10433193.json\", \"json_field\": \"abstractText\", \"text_sha256\": \"edf82df926d65731111d3f6b8005965a95e9928421170aa4cb5cef0709adc924\", \"text_characters\": 2339, \"note\": \"Exact publisher passage retained in the cited local source cache; locator and digest supplied here.\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat oral and intraperitoneal sodium iodide experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"0.05% sodium iodide in drinking water for 1 or 6 days.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Rodent pharmacological exposure; recovery time and susceptibility cannot be imposed on humans.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iodine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Rattus norvegicus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The initial hormone suppression wore off despite continued high iodide exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iodine-syn-escape1999] Escape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium/iodide symporter messenger ribonucleic acid and protein. 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