{"id":"6d08d398-c41a-5b30-9b71-86fbcc73914a","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:thiamine-def-large-fiber-neuropathy-pathology","predicate":"deficiency-associated-with","statement":"Large-fiber-predominant axonal loss characterized the thiamine-deficiency group, whereas small-fiber loss predominated in the pure alcoholic-neuropathy group.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"3e6d01fa-1ca1-5d88-af61-566e7aa4e230","mechanism_event_label":"The nerve biopsies also distinguished the dominant injury patterns.","subject":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"object":{"id":"e80054be-bc5f-56f1-bcd4-ee370c9430be","slug":"peripheral-large-axon-loss","display_name":"Peripheral large-fiber axonal loss","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3e6d01fa-1ca1-5d88-af61-566e7aa4e230","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:thiamine-def-large-fiber-neuropathy-pathology-event","event_type":"observed_intervention","label":"The nerve biopsies also distinguished the dominant injury patterns.","description":"Large-fiber-predominant axonal loss characterized the thiamine-deficiency group, whereas small-fiber loss predominated in the pure alcoholic-neuropathy group.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e80054be-bc5f-56f1-bcd4-ee370c9430be","slug":"peripheral-large-axon-loss","display_name":"Peripheral large-fiber axonal loss","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_location","value_text":"Abstract: sural-nerve pathology comparison","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"Large-fiber-predominant axonal loss predominated in TDN","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Clinical and sural-nerve pathology comparison of 64 alcoholic-neuropathy patients subdivided by coexisting thiamine deficiency and 32 nonalcoholic thiamine-deficiency neuropathy patients.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Nonalcoholic thiamine-deficiency neuropathy identified in a clinical cohort","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Biopsy association does not identify a single biochemical injury step or imply that every thiamine-deficient patient loses only large fibers.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Thiamine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The nerve biopsies also distinguished the dominant injury patterns.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[koike-2003-neuropathy-subtypes] Alcoholic neuropathy is clinicopathologically distinct from thiamine-deficiency neuropathy (2003). https://pubmed.ncbi.nlm.nih.gov/12838517/ DOI: 10.1002/ana.10550","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Sural nerve biopsy specimens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"0a983a46-c24f-5458-b7d5-f716280e73cf","evidence_kind":"source_excerpt","locator":"Lines 1549-1561","start_line":1549,"end_line":1561,"excerpt":"### thiamine-def-large-fiber-neuropathy-pathology\nLarge-fiber-predominant axonal loss characterized the thiamine-deficiency group, whereas small-fiber loss predominated in the pure alcoholic-neuropathy group.\nCondition category: nutrient_deficiency\nnutrient_topic: Thiamine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The nerve biopsies also distinguished the dominant injury patterns.\norganism: Homo sapiens\ntissue_or_cell_type: Sural nerve biopsy specimens\nexperimental_model: Clinical and sural-nerve pathology comparison of 64 alcoholic-neuropathy patients subdivided by coexisting thiamine deficiency and 32 nonalcoholic thiamine-deficiency neuropathy patients.\nlimitations: Biopsy association does not identify a single biochemical injury step or imply that every thiamine-deficient patient loses only large fibers.\nevidence_location: Abstract: sural-nerve pathology comparison\nevidence_span: Large-fiber-predominant axonal loss predominated in TDN\nexposure: Nonalcoholic thiamine-deficiency neuropathy identified in a clinical cohort\n[koike-2003-neuropathy-subtypes] Alcoholic neuropathy is clinicopathologically distinct from thiamine-deficiency neuropathy (2003). https://pubmed.ncbi.nlm.nih.gov/12838517/ DOI: 10.1002/ana.10550","model_system":"Clinical and sural-nerve pathology comparison of 64 alcoholic-neuropathy patients subdivided by coexisting thiamine deficiency and 32 nonalcoholic thiamine-deficiency neuropathy patients.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [koike-2003-neuropathy-subtypes] Alcoholic neuropathy is clinicopathologically distinct from thiamine-deficiency neuropathy (2003). https://pubmed.ncbi.nlm.nih.gov/12838517/ DOI: 10.1002/ana.10550","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"158d2c03-ac8c-589f-8270-c468165ae346","stable_key":"import-46d15d9e-d3b5-544d-ba01-b785aa3e4f42","title":"Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f376512fb3310141315548015b387833e3af45146e73fb73cd02cee20e4ddb9c","revision_id":"53bc5eda-dec8-58cc-a56f-a9eb4ab036ef","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}