{"id":"6cf8cb3d-c90d-5aee-8a1e-379f7c98ee54","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:e-clin-hope-heart-failure","predicate":"increases_observed","statement":"Vitamin E assignment was associated with more heart failure in HOPE/HOPE-TOO (RR 1.13, 95% CI 1.01–1.26).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"15653411-3b20-57a7-a457-7b1dc3773ab4","mechanism_event_label":"Heart failure was more frequent with the tested regimen in this high-risk trial.","subject":{"id":"e67a0437-6900-5f53-8b03-c0a7ad6d92b6","slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"},"object":{"id":"5cd5a019-58fe-5219-8d5c-0a4c079b2be3","slug":"heart-failure-incidence","display_name":"Heart failure incidence","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"15653411-3b20-57a7-a457-7b1dc3773ab4","stable_key":"e0ea2d6a-7429-5e9f-b774-41e5e3288da3:e-clin-hope-heart-failure-event","event_type":"observed_intervention","label":"Heart failure was more frequent with the tested regimen in this high-risk trial.","description":"Vitamin E assignment was associated with more heart failure in HOPE/HOPE-TOO (RR 1.13, 95% CI 1.01–1.26).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e67a0437-6900-5f53-8b03-c0a7ad6d92b6","slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5cd5a019-58fe-5219-8d5c-0a4c079b2be3","slug":"heart-failure-incidence","display_name":"Heart failure incidence","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"HOPE/HOPE-TOO randomized trial and extension in vascular disease or diabetes; initial n=9541","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Natural-source vitamin E 400 IU/day; median follow-up 7 years; extension included ongoing treatment and passive follow-up.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"High-risk population and extension participation limits. Heart failure was a secondary outcome; no specific molecular cause is established by the trial. Natural-source vitamin E is reported; an exact ester identity is not inferred from the abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin E research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Heart failure was more frequent with the tested regimen in this high-risk trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[e-clin-hope2005] Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. (2005). https://pubmed.ncbi.nlm.nih.gov/15769967/ DOI: 10.1001/jama.293.11.1338","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Cardiovascular clinical events","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c086066a-caa6-5ef8-87a9-9547be7ec0be","evidence_kind":"source_excerpt","locator":"Lines 1388-1399","start_line":1388,"end_line":1399,"excerpt":"### e-clin-hope-heart-failure\nVitamin E assignment was associated with more heart failure in HOPE/HOPE-TOO (RR 1.13, 95% CI 1.01–1.26).\nCondition category: normal\nnutrient_topic: Vitamin E research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Heart failure was more frequent with the tested regimen in this high-risk trial.\norganism: Homo sapiens\ntissue_or_cell_type: Cardiovascular clinical events\nexperimental_model: HOPE/HOPE-TOO randomized trial and extension in vascular disease or diabetes; initial n=9541\nlimitations: High-risk population and extension participation limits. Heart failure was a secondary outcome; no specific molecular cause is established by the trial. Natural-source vitamin E is reported; an exact ester identity is not inferred from the abstract.\nexposure: Natural-source vitamin E 400 IU/day; median follow-up 7 years; extension included ongoing treatment and passive follow-up.\ncross_nutrient: false\n[e-clin-hope2005] Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. (2005). https://pubmed.ncbi.nlm.nih.gov/15769967/ DOI: 10.1001/jama.293.11.1338","model_system":"HOPE/HOPE-TOO randomized trial and extension in vascular disease or diabetes; initial n=9541","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [e-clin-hope2005] Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. (2005). https://pubmed.ncbi.nlm.nih.gov/15769967/ DOI: 10.1001/jama.293.11.1338","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3ac41dba-4727-5116-a556-ac3bbb0dc41c","stable_key":"import-e0ea2d6a-7429-5e9f-b774-41e5e3288da3","title":"Vitamin E: transport, membrane protection and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a90b6565e092c6a2da07f74cf758792c2cf63b40746260c8ff12bd64322c36f4","revision_id":"956793d1-23e4-5397-9291-25c1732a8e02","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}