{"id":"6cbd6e48-981c-53f9-b199-26e1e636f703","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-human-osteoclast","predicate":"reduces","statement":"Strontium inhibited maturation, TRAP expression and hydroxyapatite resorption in human blood-derived osteoclast cultures.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8cfa2f21-00a5-528f-a152-03c7637713c1","mechanism_event_label":"The human-cell study measured function as well as a marker.","subject":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"object":{"id":"1546b799-1a34-5d1b-a54d-01c0d364bc86","slug":"human-strontium-osteoclast-function","display_name":"Maturation, TRAP activity and resorption in human osteoclast cultures","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8cfa2f21-00a5-528f-a152-03c7637713c1","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-human-osteoclast-event","event_type":"observed_relationship","label":"The human-cell study measured function as well as a marker.","description":"Strontium inhibited maturation, TRAP expression and hydroxyapatite resorption in human blood-derived osteoclast cultures.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1546b799-1a34-5d1b-a54d-01c0d364bc86","slug":"human-strontium-osteoclast-function","display_name":"Maturation, TRAP activity and resorption in human osteoclast cultures","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2ca2864b-1ef0-54e4-8397-1dbe7207a0d2","slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"1c0d5c58-d358-5501-9bdf-8999bcf79fd4","slug":"casr","display_name":"Calcium-sensing receptor / CaSR","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human blood-derived osteoclast assays paired with HEK293 receptor signaling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cell-culture effects do not independently establish fracture reduction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Strontium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"The human-cell study measured function as well as a marker.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Divergent effects of strontium and calcium-sensing receptor positive allosteric modulators (calcimimetics) on human osteoclast activity. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29714810/ · DOI 10.1111/bph.14344","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"bbf21bc4-349a-5629-b021-33f1cdebdec4","evidence_kind":"source_excerpt","locator":"Lines 254-260","start_line":254,"end_line":260,"excerpt":"## strontium-human-osteoclast\nThe human-cell study measured function as well as a marker.\nStrontium inhibited maturation, TRAP expression and hydroxyapatite resorption in human blood-derived osteoclast cultures.\nModel: Human blood-derived osteoclast assays paired with HEK293 receptor signaling.\nLimitations: Cell-culture effects do not independently establish fracture reduction.\nEvidence access: Primary abstract\nDivergent effects of strontium and calcium-sensing receptor positive allosteric modulators (calcimimetics) on human osteoclast activity. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29714810/ · DOI 10.1111/bph.14344","model_system":"Human blood-derived osteoclast assays paired with HEK293 receptor signaling.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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