{"id":"6c9358f5-178b-50b9-afc1-900d266ad6a3","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-qprt-injury","predicate":"declines_during_injury","statement":"Mouse acute kidney injury reduced renal QPRT and NAD while quinolinate accumulated.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8f501e28-ad83-5683-b3b4-76e7d49ec4cd","mechanism_event_label":"An upstream metabolite can rise while the useful downstream product falls.","subject":{"id":"0d90b4b2-8b33-5127-9d33-bceadab0af03","slug":"mouse-qprt","display_name":"Mouse quinolinate phosphoribosyltransferase / Qprt","entity_type_key":"protein"},"object":{"id":"e87b8b33-00ba-5e66-88cc-d287deec1d9a","slug":"mouse-renal-nad","display_name":"Mouse renal NAD abundance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8f501e28-ad83-5683-b3b4-76e7d49ec4cd","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-qprt-injury-event","event_type":"observed_relationship","label":"An upstream metabolite can rise while the useful downstream product falls.","description":"Mouse acute kidney injury reduced renal QPRT and NAD while quinolinate accumulated.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0d90b4b2-8b33-5127-9d33-bceadab0af03","slug":"mouse-qprt","display_name":"Mouse quinolinate phosphoribosyltransferase / Qprt","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e87b8b33-00ba-5e66-88cc-d287deec1d9a","slug":"mouse-renal-nad","display_name":"Mouse renal NAD abundance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"769339cb-213b-559e-acc0-07ed00368b94","slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"ab444b3c-c8ec-5ada-8450-36ac9934d6b6","slug":"quinolinic-acid","display_name":"Quinolinic acid","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse acute kidney injury measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Co-occurrence alone is not the complete causal test; Qprt dosage manipulation is recorded separately.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Tryptophan collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"An upstream metabolite can rise while the useful downstream product falls.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"De novo NAD+ biosynthetic impairment in acute kidney injury in humans. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30127395/ · DOI 10.1038/s41591-018-0138-z","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"b70894f2-58f0-5734-8e1e-aeb74b5e4dd0","evidence_kind":"source_excerpt","locator":"Lines 242-248","start_line":242,"end_line":248,"excerpt":"## tryptophan-qprt-injury\nAn upstream metabolite can rise while the useful downstream product falls.\nMouse acute kidney injury reduced renal QPRT and NAD while quinolinate accumulated.\nModel: Mouse acute kidney injury measurements.\nLimitations: Co-occurrence alone is not the complete causal test; Qprt dosage manipulation is recorded separately.\nEvidence access: Primary abstract\nDe novo NAD+ biosynthetic impairment in acute kidney injury in humans. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30127395/ · DOI 10.1038/s41591-018-0138-z","model_system":"Mouse acute kidney injury measurements.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"73f9d3e7-fdc9-5418-8f3c-f4ef145f6efa","stable_key":"import-584c58f5-ab9f-53f3-97a9-55783db943b0","title":"Tryptophan: transport, protein synthesis, neuroactive metabolites, NAD and microbial pathways (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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