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(2013). https://pubmed.ncbi.nlm.nih.gov/23741301/ DOI: 10.1371/journal.pone.0064045","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Engineered DT40-cell zinc compartments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"ff1ad249-2c55-5e7e-8ed3-71ae64cbe90e","evidence_kind":"source_excerpt","locator":"Lines 336-347","start_line":336,"end_line":347,"excerpt":"### zinc-trans-znt2-w152r-transport\nHuman ZnT2 W152R lost zinc transport activity in zinc-sensitive DT40 cells.\nCondition category: machinery_impairment\nnutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: One maternal ZnT2 variant could no longer move zinc in the test cells.\norganism: Human protein in Gallus gallus cells\ntissue_or_cell_type: Engineered DT40-cell zinc compartments\nexperimental_model: Human ZnT2 constructs in zinc-sensitive chicken DT40 cells; sequence reference NP_001004434\nlimitations: Model tests intrinsic variant function; DT40 survival/compartment readouts are not direct measurement of zinc secretion into human milk.\nexposure: W152R compared with wild type; functional complementation and zinc-handling assays.\ncross_nutrient: false\n[zinc-trans-23741301] Compound heterozygous mutations in SLC30A2/ZnT2 results in low milk zinc concentrations: a novel mechanism for zinc deficiency in a breast-fed infant. (2013). https://pubmed.ncbi.nlm.nih.gov/23741301/ DOI: 10.1371/journal.pone.0064045","model_system":"Human ZnT2 constructs in zinc-sensitive chicken DT40 cells; sequence reference NP_001004434","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [zinc-trans-23741301] Compound heterozygous mutations in SLC30A2/ZnT2 results in low milk zinc concentrations: a novel mechanism for zinc deficiency in a breast-fed infant. (2013). https://pubmed.ncbi.nlm.nih.gov/23741301/ DOI: 10.1371/journal.pone.0064045","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c5ee0fee-ce5c-58de-905a-10fb0ea0723c","stable_key":"import-6d38d43e-01e4-5641-93be-65654271e242","title":"Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"2e731dd54477ec1254e97df3323e1208d38f1375effed19252e71ab4f600d13a","revision_id":"c72258b9-ac09-5408-9d44-a921ad1f96a3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}